| Literature DB >> 30510256 |
Lucas D Trucco1, Piyushkumar A Mundra1, Kate Hogan1, Pablo Garcia-Martinez1, Amaya Viros1, Amit K Mandal1, Nicolas Macagno2, Caroline Gaudy-Marqueste3, Donald Allan4, Franziska Baenke1, Martin Cook1, Clare McManus1, Berta Sanchez-Laorden1, Nathalie Dhomen1, Richard Marais5.
Abstract
The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.Entities:
Mesh：
Year: 2018 PMID： 30510256 DOI： 10.1038/s41591-018-0265-6
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440