| Literature DB >> 30509493 |
Sumeng Gao1, Hongyan Lin1, Wang Yu1, Fangfang Zhang1, Ruoyang Wang1, Herbert Yu2, Biyun Qian3.
Abstract
Cigarette smoking plays an important role in the process of lung cancer, during which DNA damage is proved to be involved. Non-coding RNAs are found to be involved in the DNA damage and repair processes induced by cigarette smoke. In the present study, we investigated the role of lncRNA LCPAT1 in DNA damage caused by CSE in Beas-2B cells. Our results indicate that LCPAT1, through RCC2 is involved in the CSE-induced DNA damage providing new insight into the lung carcinogenesis related to cigarette smoking.Entities:
Keywords: Cigarette smoke; DNA damage; LCAPT1; Lung carcinogenesis
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Year: 2018 PMID: 30509493 DOI: 10.1016/j.bbrc.2018.11.171
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN: 0006-291X Impact factor: 3.575