Marco Durante1, Harald Paganetti2, Arnold Pompos3, Stephen F Kry4, Xiaodong Wu5, David R Grosshans6. 1. Biophysics Department, GSI Helmholtzzentrum für Schwerionenforschung and Technische Universität Darmstadt, Institute of Condensed Matter Physics, Planckstraße 1, 64291, Darmstadt, Germany. 2. Department of Radiation Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, 02114, USA. 3. Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. 4. Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. 5. Department of Medical Physics, Shanghai Proton and Heavy Ion Center, Shanghai, China. 6. Departments of Radiation and Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.
Abstract
PURPOSE: To define the physical parameters needed to characterize a particle beam in order to allow intercomparison of different experiments performed using different ions at the same facility and using the same ion at different facilities. METHODS: At the request of the National Cancer Institute (NCI), a special panel was convened to review the current status of the field and to provide suggested metrics for reporting the physical parameters of particle beams to be used for biological research. A set of physical parameters and measurements that should be performed by facilities and understood and reported by researchers supported by NCI to perform pre-clinical radiobiology and medical physics of heavy ions were generated. RESULTS: Standard measures such as radiation delivery technique, beam modifiers used, nominal energy, field size, physical dose and dose rate should all be reported. However, more advanced physical measurements, including detailed characterization of beam quality by microdosimetric spectrum and fragmentation spectra, should also be established and reported. Details regarding how such data should be incorporated into Monte Carlo simulations and the proper reporting of simulation details are also discussed. CONCLUSIONS: In order to allow for a clear relation of physical parameters to biological effects, facilities and researchers should establish and report detailed physical characteristics of the irradiation beams utilized including both standard and advanced measures. Biological researchers are encouraged to actively engage facility staff and physicists in the design and conduct of experiments. Modeling individual experimental setups will allow for the reporting of the uncertainties in the measurement or calculation of physical parameters which should be routinely reported.
PURPOSE: To define the physical parameters needed to characterize a particle beam in order to allow intercomparison of different experiments performed using different ions at the same facility and using the same ion at different facilities. METHODS: At the request of the National Cancer Institute (NCI), a special panel was convened to review the current status of the field and to provide suggested metrics for reporting the physical parameters of particle beams to be used for biological research. A set of physical parameters and measurements that should be performed by facilities and understood and reported by researchers supported by NCI to perform pre-clinical radiobiology and medical physics of heavy ions were generated. RESULTS: Standard measures such as radiation delivery technique, beam modifiers used, nominal energy, field size, physical dose and dose rate should all be reported. However, more advanced physical measurements, including detailed characterization of beam quality by microdosimetric spectrum and fragmentation spectra, should also be established and reported. Details regarding how such data should be incorporated into Monte Carlo simulations and the proper reporting of simulation details are also discussed. CONCLUSIONS: In order to allow for a clear relation of physical parameters to biological effects, facilities and researchers should establish and report detailed physical characteristics of the irradiation beams utilized including both standard and advanced measures. Biological researchers are encouraged to actively engage facility staff and physicists in the design and conduct of experiments. Modeling individual experimental setups will allow for the reporting of the uncertainties in the measurement or calculation of physical parameters which should be routinely reported.
Authors: Elisabeth Mara; Monika Clausen; Suphalak Khachonkham; Simon Deycmar; Clara Pessy; Wolfgang Dörr; Peter Kuess; Dietmar Georg; Sylvia Gruber Journal: Med Phys Date: 2020-05-15 Impact factor: 4.071
Authors: Lianghao Ding; Brock J Sishc; Elizabeth Polsdofer; John S Yordy; Angelica Facoetti; Mario Ciocca; Debabrata Saha; Arnold Pompos; Anthony J Davis; Michael D Story Journal: Front Oncol Date: 2022-02-25 Impact factor: 6.244
Authors: Harald Paganetti; Chris Beltran; Stefan Both; Lei Dong; Jacob Flanz; Keith Furutani; Clemens Grassberger; David R Grosshans; Antje-Christin Knopf; Johannes A Langendijk; Hakan Nystrom; Katia Parodi; Bas W Raaymakers; Christian Richter; Gabriel O Sawakuchi; Marco Schippers; Simona F Shaitelman; B K Kevin Teo; Jan Unkelbach; Patrick Wohlfahrt; Tony Lomax Journal: Phys Med Biol Date: 2021-02-26 Impact factor: 4.174