Lei Shi1,2,3, Feng-Lei Du4, Zong-Wen Sun5, Lan Zhang6, Yuan-Yuan Chen3,4, Tie-Ming Xie2,3, Pei-Jing Li2, Shuang Huang3,4, Bai-Qiang Dong3,4, Min-Ming Zhang1. 1. Department of Radiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China. 2. Department of Radiology, Zhejiang Cancer Hospital, Hangzhou 310022, China. 3. Zhejiang Key Laboratory of Radiation Oncology, Hangzhou 310022, China. 4. Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China. 5. Department of Oncology, Jining No.1 People's Hospital, Jining 272000, China. 6. Department of Ophthalmology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
Abstract
BACKGROUND: Gray matter (GM) damage after radiotherapy (RT) in nasopharyngeal carcinoma (NPC) patients can result in cognitive impairment, while there may be no visible brain tissue change according to the conventional magnetic resonance imaging (MRI). This study investigated radiation-induced GM volume differences between NPC patients who received RT and those who did not. METHODS: High-resolution brain structural MRI data from two groups of patients were acquired. The pre-RT group was composed of 56 newly diagnosed but not yet medically treated NPC patients, while the after-RT group consisted of 40 NPC patients who had completed RT more than 1 year ago. Voxel-based morphometry (VBM) was applied to assess GM volumes. Two sample t-test was used to analyze GM volumes voxel-by-voxel using the VBM8 toolbox built in the SPM software. Radiation-induced cortical volume alteration in all NPC patients after RT and dosimetry of 36 patients were analyzed. RESULTS: Compared to pre-treatment group, cortical volumes of GM were significantly smaller in the left hippocampus, the right pulvinar and the right middle temporal gyrus (MTG, P<0.001, AlphaSim correction, cluster size ≥157). The mean dose (Dmean) for bilateral hippocampal heads were significantly higher than other different parts of the brain (P<0.001). No significant correlations between the GM volume in any brain regions and the mean dose of corresponding position of these brain regions were observed (P>0.05). CONCLUSIONS: Radiation to the NPC patients can not only induce damage of the hippocampus, but also other secondary damages of GM.
BACKGROUND: Gray matter (GM) damage after radiotherapy (RT) in nasopharyngeal carcinoma (NPC) patients can result in cognitive impairment, while there may be no visible brain tissue change according to the conventional magnetic resonance imaging (MRI). This study investigated radiation-induced GM volume differences between NPC patients who received RT and those who did not. METHODS: High-resolution brain structural MRI data from two groups of patients were acquired. The pre-RT group was composed of 56 newly diagnosed but not yet medically treated NPC patients, while the after-RT group consisted of 40 NPC patients who had completed RT more than 1 year ago. Voxel-based morphometry (VBM) was applied to assess GM volumes. Two sample t-test was used to analyze GM volumes voxel-by-voxel using the VBM8 toolbox built in the SPM software. Radiation-induced cortical volume alteration in all NPC patients after RT and dosimetry of 36 patients were analyzed. RESULTS: Compared to pre-treatment group, cortical volumes of GM were significantly smaller in the left hippocampus, the right pulvinar and the right middle temporal gyrus (MTG, P<0.001, AlphaSim correction, cluster size ≥157). The mean dose (Dmean) for bilateral hippocampal heads were significantly higher than other different parts of the brain (P<0.001). No significant correlations between the GM volume in any brain regions and the mean dose of corresponding position of these brain regions were observed (P>0.05). CONCLUSIONS: Radiation to the NPC patients can not only induce damage of the hippocampus, but also other secondary damages of GM.
Authors: Simon S Keller; Jonathan O'Muircheartaigh; Catherine Traynor; Karren Towgood; Gareth J Barker; Mark P Richardson Journal: Epilepsia Date: 2014-01-21 Impact factor: 5.864
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Authors: A Gommlich; J Petr; F Raschke; A Seidlitz; C Jentsch; I Platzek; J van den Hoff; J Kotzerke; B Beuthien-Baumann; M Baumann; M Krause; E G C Troost Journal: MAGMA Date: 2021-03-31 Impact factor: 2.310