Literature DB >> 30503398

Ultrasound-responsive droplets for therapy: A review.

H Lea-Banks1, M A O'Reilly2, K Hynynen3.   

Abstract

The last two decades have seen the development of acoustically activated droplets, also known as phase-change emulsions, from a diagnostic tool to a therapeutic agent. Through bubble effects and triggered drug release, these superheated agents have found potential applications from oncology to neuromodulation. The aim of this review is to summarise the key developments in therapeutic droplet design and use, to discuss the current challenges slowing clinical translation, and to highlight the new frontiers progressing towards clinical implementation. The literature is summarised by addressing the droplet design criteria and by carrying out a multiparametric study of a range of droplet formulations and their associated vaporisation thresholds.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Cavitation; Focused ultrasound; Phase-change emulsions

Mesh：

Year:  2018        PMID： 30503398      PMCID： PMC6459400          DOI： 10.1016/j.jconrel.2018.11.028

Source DB:  PubMed          Journal:  J Control Release        ISSN： 0168-3659            Impact factor:   9.776


  90 in total

1.  Penicillin aerosol in the prevention and treatment of respiratory infections in allergic patients.

Authors:  S J PRIGAL; L J MORGANBESSER; F P McINTYRE
Journal:  J Allergy       Date:  1947-09

2.  A superfluorinated molecular probe for highly sensitive in vivo(19)F-MRI.

Authors:  Ilaria Tirotta; Alfonso Mastropietro; Chiara Cordiglieri; Lara Gazzera; Fulvio Baggi; Giuseppe Baselli; Maria Grazia Bruzzone; Ileana Zucca; Gabriella Cavallo; Giancarlo Terraneo; Francesca Baldelli Bombelli; Pierangelo Metrangolo; Giuseppe Resnati
Journal:  J Am Chem Soc       Date:  2014-06-06       Impact factor: 15.419

3.  A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer.

Authors:  Georg Dimcevski; Spiros Kotopoulis; Tormod Bjånes; Dag Hoem; Jan Schjøtt; Bjørn Tore Gjertsen; Martin Biermann; Anders Molven; Halfdan Sorbye; Emmet McCormack; Michiel Postema; Odd Helge Gilja
Journal:  J Control Release       Date:  2016-10-12       Impact factor: 9.776

4.  Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans.

Authors:  Wynn Legon; Tomokazu F Sato; Alexander Opitz; Jerel Mueller; Aaron Barbour; Amanda Williams; William J Tyler
Journal:  Nat Neurosci       Date:  2014-01-12       Impact factor: 24.884

5.  Methods of Generating Submicrometer Phase-Shift Perfluorocarbon Droplets for Applications in Medical Ultrasonography.

Authors:  Paul S Sheeran; Naomi Matsuura; Mark A Borden; Ross Williams; Terry O Matsunaga; Peter N Burns; Paul A Dayton
Journal:  IEEE Trans Ultrason Ferroelectr Freq Control       Date:  2016-10-20       Impact factor: 2.725

6.  Clinical trial of blood-brain barrier disruption by pulsed ultrasound.

Authors:  Alexandre Carpentier; Michael Canney; Alexandre Vignot; Vincent Reina; Kevin Beccaria; Catherine Horodyckid; Carine Karachi; Delphine Leclercq; Cyril Lafon; Jean-Yves Chapelon; Laurent Capelle; Philippe Cornu; Marc Sanson; Khê Hoang-Xuan; Jean-Yves Delattre; Ahmed Idbaih
Journal:  Sci Transl Med       Date:  2016-06-15       Impact factor: 17.956

Review 7.  Nanobio applications of quantum dots in cancer: imaging, sensing, and targeting.

Authors:  Ahmad SalmanOgli
Journal:  Cancer Nanotechnol       Date:  2011-07-13

8.  MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study.

Authors:  Nir Lipsman; Michael L Schwartz; Yuexi Huang; Liesly Lee; Tejas Sankar; Martin Chapman; Kullervo Hynynen; Andres M Lozano
Journal:  Lancet Neurol       Date:  2013-03-21       Impact factor: 44.182

9.  Drug Release from Phase-Changeable Nanodroplets Triggered by Low-Intensity Focused Ultrasound.

Authors:  Yang Cao; Yuli Chen; Tao Yu; Yuan Guo; Fengqiu Liu; Yuanzhi Yao; Pan Li; Dong Wang; Zhigang Wang; Yu Chen; Haitao Ran
Journal:  Theranostics       Date:  2018-02-02       Impact factor: 11.556

10.  Clinical trial protocol for TARDOX: a phase I study to investigate the feasibility of targeted release of lyso-thermosensitive liposomal doxorubicin (ThermoDox®) using focused ultrasound in patients with liver tumours.

Authors:  Paul C Lyon; Lucy F Griffiths; Jenni Lee; Daniel Chung; Robert Carlisle; Feng Wu; Mark R Middleton; Fergus V Gleeson; Constantin C Coussios
Journal:  J Ther Ultrasound       Date:  2017-11-02
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  18 in total

Review 1.  Ultrasonic technologies in imaging and drug delivery.

Authors:  Yi-Ju Ho; Chih-Chung Huang; Ching-Hsiang Fan; Hao-Li Liu; Chih-Kuang Yeh
Journal:  Cell Mol Life Sci       Date:  2021-07-23       Impact factor: 9.261

2.  Slow-Flow Ultrasound Localization Microscopy Using Recondensation of Perfluoropentane Nanodroplets.

Authors:  Mark T Burgess; Mitra Aliabouzar; Christian Aguilar; Mario L Fabiilli; Jeffrey A Ketterling
Journal:  Ultrasound Med Biol       Date:  2022-02-04       Impact factor: 2.998

3.  Acoustic properties across the human skull.

Authors:  Thomas S Riis; Taylor D Webb; Jan Kubanek
Journal:  Ultrasonics       Date:  2021-10-21       Impact factor: 2.890

4.  Ultrasound-triggered oxygen-loaded nanodroplets enhance and monitor cerebral damage from sonodynamic therapy.

Authors:  Harriet Lea-Banks; Sheng-Kai Wu; Hannah Lee; Kullervo Hynynen
Journal:  Nanotheranostics       Date:  2022-06-27

5.  Polyvinyl Alcohol Cryogels for Acoustic Characterization of Phase-Change Contrast Agents.

Authors:  Phillip G Durham; Jinwook Kim; Katherine M Eltz; Charles F Caskey; Paul A Dayton
Journal:  Ultrasound Med Biol       Date:  2022-03-01       Impact factor: 3.694

6.  Ultrasound-sensitive nanodroplets achieve targeted neuromodulation.

Authors:  Harriet Lea-Banks; Ying Meng; Sheng-Kai Wu; Rania Belhadjhamida; Clement Hamani; Kullervo Hynynen
Journal:  J Control Release       Date:  2021-02-16       Impact factor: 9.776

Review 7.  Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery.

Authors:  Klazina Kooiman; Silke Roovers; Simone A G Langeveld; Robert T Kleven; Heleen Dewitte; Meaghan A O'Reilly; Jean-Michel Escoffre; Ayache Bouakaz; Martin D Verweij; Kullervo Hynynen; Ine Lentacker; Eleanor Stride; Christy K Holland
Journal:  Ultrasound Med Biol       Date:  2020-03-10       Impact factor: 2.998

8.  Repeated Acoustic Vaporization of Perfluorohexane Nanodroplets for Contrast-Enhanced Ultrasound Imaging.

Authors:  Austin Van Namen; Sidhartha Jandhyala; Tomas Jordan; Geoffrey P Luke
Journal:  IEEE Trans Ultrason Ferroelectr Freq Control       Date:  2021-11-23       Impact factor: 2.725

9.  Combined gas embolization and chemotherapy can result in complete tumor regression in a murine hepatocellular carcinoma model.

Authors:  Jonah S Harmon; Foad Kabinejadian; Joseph L Bull
Journal:  APL Bioeng       Date:  2020-09-08

10.  Localized anesthesia of a specific brain region using ultrasound-responsive barbiturate nanodroplets.

Authors:  Harriet Lea-Banks; Meaghan A O'Reilly; Clement Hamani; Kullervo Hynynen
Journal:  Theranostics       Date:  2020-02-03       Impact factor: 11.556
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