Maciej Serda1,2, Matthew J Ware3, Jared M Newton3,4,5, Sanchit Sachdeva3, Martyna Krzykawska-Serda3,6, Lam Nguyen3, Justin Law3, Andrew O Anderson3, Steven A Curley1,3,7, Lon J Wilson1, Stuart J Corr1,3,8,9. 1. Department of Chemistry & Smalley-Curl Institute, Rice University, Houston, TX 77251, USA. 2. Institute of Chemistry, University of Silesia in Katowice, Katowice, 40-006, Poland. 3. Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA. 4. Department of Otolaryngology-Head & Neck Surgery, Baylor College of Medicine, Houston, TX 77030, USA. 5. Interdepartmental Graduate Program in Translational Biology & Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA. 6. Faculty of Biochemistry, Biophysics & Biotechnology, Jagiellonian University, Kraków, 30-387, Poland. 7. Department of Mechanical Engineering & Materials Science, Rice University, Houston, TX 77005, USA. 8. Department of Biomedical Engineering, University of Houston, Houston 77204, TX, USA. 9. School of Medicine, Swansea University, Swansea, Wales, SA2 8PP, UK.
Abstract
AIM: Glycoconjugated C60 derivatives are of particular interest as potential cancer targeting agents due to an upregulated metabolic glucose demand, especially in the case of pancreatic adenocarcinoma and its dense stroma, which is known to be driven by a subset of pancreatic stellate cells. MATERIALS & METHODS: Herein, we describe the synthesis and biological characterization of a hexakis-glucosamine C60 derivative (termed 'Sweet-C60'). RESULTS: Synthesized fullerene derivative predominantly accumulates in the nucleus of pancreatic stellate cells; is inherently nontoxic up to concentrations of 1 mg/ml; and is photoactive when illuminated with blue and green light, allowing its use as a photodynamic therapy agent. CONCLUSION: Obtained glycoconjugated nanoplatform is a promising nanotherapeutic for pancreatic cancer.
AIM: Glycoconjugated C60 derivatives are of particular interest as potential cancer targeting agents due to an upregulated metabolic glucose demand, especially in the case of pancreatic adenocarcinoma and its dense stroma, which is known to be driven by a subset of pancreatic stellate cells. MATERIALS & METHODS: Herein, we describe the synthesis and biological characterization of a hexakis-glucosamine C60 derivative (termed 'Sweet-C60'). RESULTS: Synthesized fullerene derivative predominantly accumulates in the nucleus of pancreatic stellate cells; is inherently nontoxic up to concentrations of 1 mg/ml; and is photoactive when illuminated with blue and green light, allowing its use as a photodynamic therapy agent. CONCLUSION: Obtained glycoconjugated nanoplatform is a promising nanotherapeutic for pancreatic cancer.
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