Literature DB >> 15984854

Destroying gadofullerene aggregates by salt addition in aqueous solution of Gd@C(60)(OH)(x) and Gd@C(60)[C(COOH(2))](10).

Sabrina Laus1, Balaji Sitharaman, Eva Tóth, Robert D Bolskar, Lothar Helm, Subashini Asokan, Michael S Wong, Lon J Wilson, André E Merbach.   

Abstract

A combined proton relaxivity and dynamic light scattering study has shown that aggregates formed in aqueous solution of water-soluble gadofullerenes can be disrupted by addition of salts. The salt content of fullerene-based materials will strongly influence properties related to aggregation phenomena, therefore, their behavior in biological or medical applications. In particular, the relaxivity of gadofullerenes decreases dramatically with phosphate addition. Moreover, real biological fluids present a rather high salt concentration which will have consequences on fullerene aggregation and influence fullerene-based drug delivery.

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Year:  2005        PMID： 15984854      PMCID： PMC2597542          DOI： 10.1021/ja052388+

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  10 in total

1.  In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers.

Authors:  D W Cagle; S J Kennel; S Mirzadeh; J M Alford; L J Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-27       Impact factor: 11.205

2.  Highly-iodinated fullerene as a contrast agent for X-ray imaging.

Authors:  Tim Wharton; Lon J Wilson
Journal:  Bioorg Med Chem       Date:  2002-11       Impact factor: 3.641

3.  Lanthanoid endohedral metallofullerenols for MRI contrast agents.

Authors:  Haruhito Kato; Yoko Kanazawa; Masafumi Okumura; Atsushi Taninaka; Takashi Yokawa; Hisanori Shinohara
Journal:  J Am Chem Soc       Date:  2003-04-09       Impact factor: 15.419

4.  Paramagnetic water-soluble metallofullerenes having the highest relaxivity for MRI contrast agents.

Authors:  M Mikawa; H Kato; M Okumura; M Narazaki; Y Kanazawa; N Miwa; H Shinohara
Journal:  Bioconjug Chem       Date:  2001 Jul-Aug       Impact factor: 4.774

5.  Polyhydroxylated C(60), fullerenols, as glutamate receptor antagonists and neuroprotective agents.

Authors:  H Jin; W Q Chen; X W Tang; L Y Chiang; C Y Yang; J V Schloss; J Y Wu
Journal:  J Neurosci Res       Date:  2000-11-15       Impact factor: 4.164

6.  Synthesis and in vitro characterization of a tissue-selective fullerene: vectoring C(60)(OH)(16)AMBP to mineralized bone.

Authors:  Kelly A Gonzalez; Lon J Wilson; Wenju Wu; George H Nancollas
Journal:  Bioorg Med Chem       Date:  2002-06       Impact factor: 3.641

7.  Water-soluble gadofullerenes: toward high-relaxivity, pH-responsive MRI contrast agents.

Authors:  Eva Tóth; Robert D Bolskar; Alain Borel; Gabriel González; Lothar Helm; André E Merbach; Balaji Sitharaman; Lon J Wilson
Journal:  J Am Chem Soc       Date:  2005-01-19       Impact factor: 15.419

8.  Active oxygen species generated from photoexcited fullerene (C60) as potential medicines: O2-* versus 1O2.

Authors:  Yoko Yamakoshi; Naoki Umezawa; Akemi Ryu; Kumi Arakane; Naoki Miyata; Yukihiro Goda; Toshiki Masumizu; Tetsuo Nagano
Journal:  J Am Chem Soc       Date:  2003-10-22       Impact factor: 15.419

9.  From monomers to micelles: investigation of the parameters influencing proton relaxivity.

Authors:  Gaëlle M Nicolle; Eva Tóth; Klaus-Peter Eisenwiener; Helmut R Mäcke; André E Merbach
Journal:  J Biol Inorg Chem       Date:  2002-03-23       Impact factor: 3.358

10.  First soluble M@C60 derivatives provide enhanced access to metallofullerenes and permit in vivo evaluation of Gd@C60[C(COOH)2]10 as a MRI contrast agent.

Authors:  Robert D Bolskar; Angelo F Benedetto; Lars O Husebo; Roger E Price; Edward F Jackson; Sidney Wallace; Lon J Wilson; J Michael Alford
Journal:  J Am Chem Soc       Date:  2003-05-07       Impact factor: 15.419
  10 in total
  16 in total

1.  Development of photoactive Sweet-C60 for pancreatic cancer stellate cell therapy.

Authors:  Maciej Serda; Matthew J Ware; Jared M Newton; Sanchit Sachdeva; Martyna Krzykawska-Serda; Lam Nguyen; Justin Law; Andrew O Anderson; Steven A Curley; Lon J Wilson; Stuart J Corr
Journal:  Nanomedicine (Lond)       Date:  2018-12-03       Impact factor: 5.307

Review 2.  Detecting and treating cancer with nanotechnology.

Authors:  Keith B Hartman; Lon J Wilson; Michael G Rosenblum
Journal:  Mol Diagn Ther       Date:  2008       Impact factor: 4.074

Review 3.  Macromolecules, dendrimers, and nanomaterials in magnetic resonance imaging: the interplay between size, function, and pharmacokinetics.

Authors:  Aaron Joseph L Villaraza; Ambika Bumb; Martin W Brechbiel
Journal:  Chem Rev       Date:  2010-05-12       Impact factor: 60.622

4.  Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis.

Authors:  Xing-Jie Liang; Huan Meng; Yingze Wang; Haiyong He; Jie Meng; Juan Lu; Paul C Wang; Yuliang Zhao; Xueyun Gao; Baoyun Sun; Chunying Chen; Genmei Xing; Dingwu Shen; Michael M Gottesman; Yan Wu; Jun-Jie Yin; Lee Jia
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-05       Impact factor: 11.205

5.  High relaxivity trimetallic nitride (Gd3N) metallofullerene MRI contrast agents with optimized functionality.

Authors:  Jianfei Zhang; Panos P Fatouros; Chunying Shu; Jonathan Reid; Lesley Shantell Owens; Ting Cai; Harry W Gibson; Gary L Long; Frank D Corwin; Zhi-Jian Chen; Harry C Dorn
Journal:  Bioconjug Chem       Date:  2010-04-21       Impact factor: 4.774

6.  Facile preparation of a new gadofullerene-based magnetic resonance imaging contrast agent with high 1H relaxivity.

Authors:  Chunying Shu; Frank D Corwin; Jianfei Zhang; Zhijian Chen; Jonathan E Reid; Minghao Sun; Wei Xu; Jae Hyun Sim; Chunru Wang; Panos P Fatouros; Alan R Esker; Harry W Gibson; Harry C Dorn
Journal:  Bioconjug Chem       Date:  2009-06       Impact factor: 4.774

7.  Effect of a mesitylene-based ligand cap on the relaxometric properties of Gd(III) hydroxypyridonate MRI contrast agents.

Authors:  Eric J Werner; Mauro Botta; Silvio Aime; Kenneth N Raymond
Journal:  Contrast Media Mol Imaging       Date:  2009 Sep-Oct       Impact factor: 3.161

8.  Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast.

Authors:  Jeyarama S Ananta; Biana Godin; Richa Sethi; Loick Moriggi; Xuewu Liu; Rita E Serda; Ramkumar Krishnamurthy; Raja Muthupillai; Robert D Bolskar; Lothar Helm; Mauro Ferrari; Lon J Wilson; Paolo Decuzzi
Journal:  Nat Nanotechnol       Date:  2010-10-24       Impact factor: 39.213

9.  Mechanisms of Gadographene-Mediated Proton Spin Relaxation.

Authors:  Andy H Hung; Matthew C Duch; Giacomo Parigi; Matthew W Rotz; Lisa M Manus; Daniel J Mastarone; Kevin T Dam; Colton C Gits; Keith W Macrenaris; Claudio Luchinat; Mark C Hersam; Thomas J Meade
Journal:  J Phys Chem C Nanomater Interfaces       Date:  2013-08-08       Impact factor: 4.126

10.  Dynamic aggregation of the mid-sized gadolinium complex {Ph4[Gd(DTTA)(H2O)2](-)3}.

Authors:  Hugues Jaccard; Pascal Miéville; Caroline Cannizzo; Cédric R Mayer; Lothar Helm
Journal:  J Biol Inorg Chem       Date:  2013-09-14       Impact factor: 3.358
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