Literature DB >> 30489586

The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1.

Ewelina Stefaniak1, Dawid Płonka, Simon C Drew, Karolina Bossak-Ahmad, Kathryn L Haas, M Jake Pushie, Peter Faller, Nina E Wezynfeld, Wojciech Bal.   

Abstract

Human cells acquire copper primarily via the copper transporter 1 protein, hCtr1. We demonstrate that at extracellular pH 7.4 CuII is bound to the model peptide hCtr11-14via an ATCUN motif and such complexes are strong enough to collect CuII from albumin, supporting the potential physiological role of CuII binding to hCtr1.

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Year:  2018        PMID： 30489586     DOI： 10.1039/c8mt00274f

Source DB:  PubMed          Journal:  Metallomics        ISSN： 1756-5901            Impact factor:   4.526


  7 in total

1.  A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis.

Authors:  Sarela Garcia-Santamarina; Corinna Probst; Richard A Festa; Chen Ding; Aaron D Smith; Steven E Conklin; Søren Brander; Lisa N Kinch; Nick V Grishin; Katherine J Franz; Pamela Riggs-Gelasco; Leila Lo Leggio; Katja Salomon Johansen; Dennis J Thiele
Journal:  Nat Chem Biol       Date:  2020-01-13       Impact factor: 15.040

2.  Electrospray-Induced Mass Spectrometry Is Not Suitable for Determination of Peptidic Cu(II) Complexes.

Authors:  Dawid Płonka; Radosław Kotuniak; Katarzyna Dąbrowska; Wojciech Bal
Journal:  J Am Soc Mass Spectrom       Date:  2021-11-05       Impact factor: 3.109

3.  Key Intermediate Species Reveal the Copper(II)-Exchange Pathway in Biorelevant ATCUN/NTS Complexes.

Authors:  Radosław Kotuniak; Marc J F Strampraad; Karolina Bossak-Ahmad; Urszula E Wawrzyniak; Iwona Ufnalska; Peter-Leon Hagedoorn; Wojciech Bal
Journal:  Angew Chem Int Ed Engl       Date:  2020-05-12       Impact factor: 15.336

4.  Cu(I) Controls Conformational States in Human Atox1 Metallochaperone: An EPR and Multiscale Simulation Study.

Authors:  Ortal Perkal; Zena Qasem; Meital Turgeman; Renana Schwartz; Lada Gevorkyan-Airapetov; Matic Pavlin; Alessandra Magistrato; Dan Thomas Major; Sharon Ruthstein
Journal:  J Phys Chem B       Date:  2020-05-22       Impact factor: 2.991

5.  Ionophore Ability of Carnosine and Its Trehalose Conjugate Assists Copper Signal in Triggering Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Activation In Vitro.

Authors:  Irina Naletova; Valentina Greco; Sebastiano Sciuto; Francesco Attanasio; Enrico Rizzarelli
Journal:  Int J Mol Sci       Date:  2021-12-16       Impact factor: 5.923

6.  A Deeper Insight in Metal Binding to the hCtr1 N-terminus Fragment: Affinity, Speciation and Binding Mode of Binuclear Cu2+ and Mononuclear Ag+ Complex Species.

Authors:  Antonio Magrì; Giovanni Tabbì; Irina Naletova; Francesco Attanasio; Giuseppe Arena; Enrico Rizzarelli
Journal:  Int J Mol Sci       Date:  2022-03-08       Impact factor: 5.923

Review 7.  Copper Sources for Sod1 Activation.

Authors:  Stefanie D Boyd; Morgan S Ullrich; Amelie Skopp; Duane D Winkler
Journal:  Antioxidants (Basel)       Date:  2020-06-07
  7 in total

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