Emily Kline1,2, Victoria Hendel3, Michelle Friedman-Yakoobian4,3, Raquelle I Mesholam-Gately4,3, Ann Findeisen3, Suzanna Zimmet4,3, Joanne D Wojcik4,3, Tracey L Petryshen4,5, Tsung-Ung W Woo4,3,6, Jill M Goldstein4,7, Martha E Shenton4,8,9, Matcheri S Keshavan4,3, Robert W McCarley4,9, Larry J Seidman4,3,5. 1. Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA. ekline@bidmc.harvard.edu. 2. Massachusetts Mental Health Center, Public Psychiatry Division of the Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, 02115, MA, USA. ekline@bidmc.harvard.edu. 3. Massachusetts Mental Health Center, Public Psychiatry Division of the Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, 02115, MA, USA. 4. Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA. 5. Department of Psychiatry, Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge St., Boston, 02114, MA, USA. 6. Laboratory of Cellular Neuropathology, McLean Hospital, 115 Mill St., Belmont, MA, 02478, USA. 7. Department of Medicine, Department of Psychiatry, Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, 1620 Tremont St., Boston, MA, 02120, USA. 8. Department of Psychiatry and Radiology, Brigham and Women's Hospital, 1249 Boylston Street, 02215, Boston, MA, USA. 9. VA Boston Healthcare System, 940 Belmont St., Brockton, MA, 02301, USA.
Abstract
PURPOSE: The current study evaluates the demographic, clinical, and neurocognitive characteristics of a recruited FEP research sample, a research control group, and a FEP clinic sample that were assessed and treated within the same center and time period. METHODS: This study utilized data collected through an observational study and a retrospective chart review. Samples were ascertained in the Longitudinal Assessment and Monitoring of Clinical Status and Brain Function in Adolescents and Adults study and the Prevention and Recovery in Early Psychosis clinic. FEP clinic patients (n = 77), FEP research participants (n = 44), and age-matched controls (n = 38) were assessed using the MATRICS consensus cognitive battery and global functioning social and role scales. Between-group differences were assessed via one-way ANOVA and Chi-square analyses. RESULTS: No significant differences were observed between groups with regard to age and gender. The FEP research sample had a higher proportion of white participants, better social and role functioning, and better neurocognitive performance when compared with the FEP clinical population. The clinic sample also had more diagnostic variability and higher prevalence of substance use disorders relative to the FEP research sample. CONCLUSIONS: Researchers should be aware of how study design and recruitment practices may impact the representativeness of samples, with particular concern for equal representation of racial minorities and patients with more severe illness. Studies should be designed to minimize burden to promote a wider range of participation.
PURPOSE: The current study evaluates the demographic, clinical, and neurocognitive characteristics of a recruited FEP research sample, a research control group, and a FEP clinic sample that were assessed and treated within the same center and time period. METHODS: This study utilized data collected through an observational study and a retrospective chart review. Samples were ascertained in the Longitudinal Assessment and Monitoring of Clinical Status and Brain Function in Adolescents and Adults study and the Prevention and Recovery in Early Psychosis clinic. FEP clinic patients (n = 77), FEP research participants (n = 44), and age-matched controls (n = 38) were assessed using the MATRICS consensus cognitive battery and global functioning social and role scales. Between-group differences were assessed via one-way ANOVA and Chi-square analyses. RESULTS: No significant differences were observed between groups with regard to age and gender. The FEP research sample had a higher proportion of white participants, better social and role functioning, and better neurocognitive performance when compared with the FEP clinical population. The clinic sample also had more diagnostic variability and higher prevalence of substance use disorders relative to the FEP research sample. CONCLUSIONS: Researchers should be aware of how study design and recruitment practices may impact the representativeness of samples, with particular concern for equal representation of racial minorities and patients with more severe illness. Studies should be designed to minimize burden to promote a wider range of participation.
Entities:
Keywords:
Early psychosis; Generalization; Neuroscience; Schizophrenia; Selection bias
Authors: Lynnae A Hamilton; Muktar H Aliyu; Paul D Lyons; Roberta May; Charlie L Swanson; Robert Savage; Rodney C P Go Journal: J Natl Med Assoc Date: 2006-01 Impact factor: 1.798
Authors: M C Zanarini; A E Skodol; D Bender; R Dolan; C Sanislow; E Schaefer; L C Morey; C M Grilo; M T Shea; T H McGlashan; J G Gunderson Journal: J Pers Disord Date: 2000
Authors: S Friis; I Melle; T K Larsen; U Haahr; J O Johannessen; E Simonsen; S Opjordsmoen; P Vaglum; T H McGlashan Journal: Acta Psychiatr Scand Date: 2004-10 Impact factor: 6.392
Authors: David Wendler; Raynard Kington; Jennifer Madans; Gretchen Van Wye; Heidi Christ-Schmidt; Laura A Pratt; Otis W Brawley; Cary P Gross; Ezekiel Emanuel Journal: PLoS Med Date: 2005-12-06 Impact factor: 11.069
Authors: Elizabeth J Kirkham; Catherine J Crompton; Matthew H Iveson; Iona Beange; Andrew M McIntosh; Sue Fletcher-Watson Journal: Front Psychiatry Date: 2021-06-10 Impact factor: 4.157