Yongye Sun1,2, Jianping Sun1,3, Jianxun Wang4, Tianlin Gao2, Huaqi Zhang2, Aiguo Ma5. 1. Basic Medical College, Qingdao University, Qingdao, China. 2. Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao, China. 3. Qingdao Municipal Center for Disease Control and Prevention, Qingdao, China. 4. Institute for Translational Medicine, Qingdao University, Qingdao, China. 5. Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao, China. magfood@qdu.edu.cn.
Abstract
BACKGROUND AND OBJECTIVES: The relationship between vitamin C intake and hyperuricemia among the general US adult population has seldom been reported; thus, the present study examined the associations of total vitamin C (dietary vitamin C plus supplementary vitamin C) and dietary vitamin C intake with the risk of hyperuricemia. METHODS AND STUDY DESIGN: Pooled data from three 2-year cycles (2007-2012) of the cross-sectional National Health and Nutrition Examination Survey were used in the present study. Dietary intake data were extracted from two 24-hour dietary recall interviews. Logistic regression models were used to determine the associations between vitamin C intake and hyperuricemia risk. RESULTS: A total of 14885 adults aged 20 years or older (7269 men and 7616 women) were registered in the present study. The prevalence of hyperuricemia was 19.1%. Based on the lowest quartile of dietary vitamin C intake, multivariate adjusted odds ratios with 95% confidence intervals of hyperuricemia for quartiles 2-4 were 0.84 (0.74-0.95), 0.83 (0.73-0.94), and 0.72 (0.63-0.82), and those for total vitamin C intake were 0.87 (0.77-0.99), 0.85 (0.75-0.96), and 0.66 (0.58-0.76). Inverse associations between vitamin C intake and hyperuricemia were discovered in both men and women, even with or without covariate adjustments. CONCLUSIONS: Total vitamin C and dietary vitamin C intake are inversely associated with hyperuricemia in the general US adult population.
BACKGROUND AND OBJECTIVES: The relationship between vitamin C intake and hyperuricemia among the general US adult population has seldom been reported; thus, the present study examined the associations of total vitamin C (dietary vitamin C plus supplementary vitamin C) and dietary vitamin C intake with the risk of hyperuricemia. METHODS AND STUDY DESIGN: Pooled data from three 2-year cycles (2007-2012) of the cross-sectional National Health and Nutrition Examination Survey were used in the present study. Dietary intake data were extracted from two 24-hour dietary recall interviews. Logistic regression models were used to determine the associations between vitamin C intake and hyperuricemia risk. RESULTS: A total of 14885 adults aged 20 years or older (7269 men and 7616 women) were registered in the present study. The prevalence of hyperuricemia was 19.1%. Based on the lowest quartile of dietary vitamin C intake, multivariate adjusted odds ratios with 95% confidence intervals of hyperuricemia for quartiles 2-4 were 0.84 (0.74-0.95), 0.83 (0.73-0.94), and 0.72 (0.63-0.82), and those for total vitamin C intake were 0.87 (0.77-0.99), 0.85 (0.75-0.96), and 0.66 (0.58-0.76). Inverse associations between vitamin C intake and hyperuricemia were discovered in both men and women, even with or without covariate adjustments. CONCLUSIONS: Total vitamin C and dietary vitamin C intake are inversely associated with hyperuricemia in the general US adult population.