| Literature DB >> 30483445 |
MyoungLae Cho1, Dan-Bi Kim2, Gi-Hae Shin3, Jae-Min Kim3, Yoonhee Seo4, Soo Young Choe4, Ju Hyun Cho5, Young-Cheul Kim6, Jin-Ha Lee3, Ok-Hwan Lee3.
Abstract
In the current study investigated the protective effects of citrus based mixture drinks (CBMDs) using oxidative stress in human dermal fibroblast (HDF) cells and restraint-stressed rats. The CBMDs contained citrus bioflavonoids including narirutin and hesperidin. The cell viability of HDF cells treated with H2O2 was observed at 53.9% but treated with CBMD-1 and CBMD-2 (500 μg/mL) on H2O2 exposed HDF cells significantly increased the relative cell viability at 65.0 and 72.2%, respectively. In the treadmill test, the time spent on the electrode plate in the restraint-stressed group was analyzed 24.1 s, but restraint-stressed rats with administered CBMDs (300 mg/kg) had significantly decreased the time at 2.4 (CBMD-1) and 4.7 (CBMD-2) s, respectively. In addition, number of touches the electrode plate in restraint-stressed group was observed at 42.4 ea, but, restraint-stressed rats with administered CBMD-1 and CBMD-2 (300 mg/kg) were significantly decreased at 7.0 and 10.2 ea, respectively.Entities:
Keywords: Citrus based mixture drinks; Hesperidin; Narirutin; Oxidative stress; Restraint stress
Year: 2018 PMID： 30483445 PMCID： PMC6233418 DOI： 10.1007/s10068-018-0396-z
Source DB: PubMed Journal: Food Sci Biotechnol ISSN： 1226-7708 Impact factor: 2.391