Image-guided interstitial high-dose-rate brachytherapy in the treatment of metastatic esophageal squamous cell carcinoma.

PURPOSE: To evaluate the efficacy of computed tomography (CT)- and magnetic resonance imaging (MRI)-guided interstitial high-dose-rate brachytherapy (HDR IBT = IBT) in patients with metastatic esophageal squamous cell carcinoma.
MATERIAL AND METHODS: Eleven patients with 21 unresectable metastases of histologically proven esophageal squamous cell carcinoma were included in this retrospective study. Fourteen visceral and 7 lung metastases were treated with image-guided (CT or open MRI guidance) IBT using a 192Iridium source (single fraction irradiation). Clinical and imaging follow-up were performed every 3 months after treatment. Primary endpoint was local tumor control (LTC) and safety. Furthermore, we analyzed safety, progression-free survival (PFS), and overall survival (OS).
RESULTS: The median diameter of the target lesions was 2.2 cm (range: 0.7-6.8 cm), treated with a median D100 of 20.1 Gy (range: 10-25 Gy). During a median follow-up of 6.3 months (range: 3-21.8 months), three patients displayed local recurrences, resulting in LTC of 85.7%. Median PFS was 3.4 months and median OS after IBT was 13.7 months. No severe adverse events (grade 3+) requiring hospitalization or invasive intervention were recorded.
CONCLUSIONS: Image-guided IBT is a safe and effective treatment in patients with metastasized esophageal squamous cell carcinoma.

Purpose

Esophageal cancer (EC) is the eighth most common cancer worldwide. With an overall 5-year survival rate of 15-25%, it is the sixth leading cause of cancer-associated mortality [1]. These epidemiological data include both histological subtypes: adenocarcinoma (AC) and squamous cell carcinoma (SCC), which is the predominant type [2]. Multimodal therapy combining (neoadjuvant) chemo-/radiotherapy and resection improves the outcome in non-metastatic patients [3]. However, up to 88.9% of the patients develop metastases within 3 years after curative surgery, with a median disease-free interval after surgery of 1 year [4,5,6,7]. Due to limited therapy options, the prognosis after recurrence is extremely poor, with a median survival of 3-7 months [8,9,10]. Moreover, guidelines from the European Society for Medical Oncology (ESMO) report that palliative chemotherapy for stage IV patients is less effective for SCC than for AC. Cisplatin-based combinations tend to show an increased response rate but no benefit regarding survival; therefore, either best supportive care or monotherapy should be considered in ESCC [11]. In contrast, in various tumor entities metastases limited in number and extent (i.e. oligometastases) are increasingly considered suitable for localized therapy with possible curative intent or at least systemic control, e.g. colorectal cancer [12,13]. Such localized therapy might include surgery but also image-guided local ablation techniques like radiofrequency ablation or high-dose-rate brachytherapy (IBT). However, resection is not possible in majority of patients due to distribution of metastases, contraindications for surgery, or general anesthesia, apart from surgery-associated morbidity and mortality. IBT of parenchymal organs is a relatively new technique, where an 192Iridium source is inserted directly in metastatic lesion through percutaneously implanted applicators, placed in an image-guided minimal invasive intervention, and allowing a well-defined single fraction irradiation of the target volume. IBT has already been shown to be an efficient, yet gentle treatment with a minimum of complications in ablation of metastases of various tumors, e.g. colorectal cancer or malignant melanoma, or even gastroesophageal adenocarcinoma [14,15,16]. To our knowledge, no data has been published so far evaluating the efficacy of IBT in the treatment of visceral and lung metastases of SCC. In this study, we analyzed safety and efficacy in a cohort of 11 patients with 21 unresectable SCC metastases, who underwent image-guided IBT.

Material and methods

Eligibility criteria and patients

Inclusion criteria were: 1. Technically unrespectable metastases; 2. Surgery refusal or medical contraindication for resection or comorbidities; 3. The Eastern Cooperative Oncology Group (ECOG) performance status below 2; 4. Appropriate coagulation parameters (i.e. platelet count above 50 000/nl, Quick > 50%, partial thromboplastin time > 5 seconds) and liver parameters (bilirubin < 30 μmol/l); 5. Sufficient lung capacity in case of ablation of pulmonary metastases (FEV1 > 1.5 l). There were no limitations placed upon size or location of the lesions. Contraindications were as follows: 1. Peritoneal carcinomatosis; 2. Extensive uncontrollable systemic disease; 3. Lack of consent. With respect to these criteria, we included 11 patients in this retrospective study (all male; mean age: 64.7 years; range: 52-77) with 21 unresectable metastases, treated with computed tomography (CT)- and magnetic resonance imaging (MRI)-guided IBT between April 2009 and June 2017. We treated a total of 14 visceral metastases (including 9 liver lesions, 4 lymph node metastases, and one lesion located in the adrenal gland) and 7 lung metastases. A positive opinion from the ethics committee for the analysis of the patients’ data was obtained. All patients were discussed in an interdisciplinary tumor conference, where the indication for IBT was determined. All patients were presented with histologically proven SCC and displayed tumor progression at the time of referral to our institution.

Prior to local ablation, ten patients received radiation of the primary tumor and 4 patients underwent surgical resection of the primary tumor. Furthermore, all patients had undergone palliative or adjuvant chemotherapy before IBT (detailed patient characteristics are presented in Table 1). Due to the size and location, two liver lesions were treated with MRI-guided IBT (maximum diameter 1.2 cm and 1 cm, respectively) and other lesions were visualized with CT. Prior to local ablation, all patients received a full clinical status evaluation with a physical examination, laboratory assessment, whole body contrast enhanced CT, and a Gb-EOB-DTPA enhanced MRI of the liver (Primovist®, Bayer, Pharma, Leverkusen, Germany). All patients undergoing IBT of lung lesions had a clinically full-compensated lung function.

Table 1

Patients characteristics

Patient	Sex	Age (years)	M1	Chemotherapy before IBT	Localization of target lesion	Number of lesions	Max diameter (cm)	Number of caterers used per lesion	Dose appl. (Gy)	Median follow-up (months)
1	M	59	synchron	carboplatin, paclitaxel	liver	1	4.1	3	20.5	3.1
2	M	52	metachron	cisplatin, fluorouracil	lung, lymph node	2	5.8/2.6	3/2	11.3/10	3.2
3	M	77	metachron	carboplatin, paclitaxel, cisplatin, fluorouracil	liver	1	6.3	5	22.5	5.6
4	M	72	metachron	carboplatin, paclitaxel, cisplatin, fluorouracil	adrenal gland	1	3.4	3	20.1	6.9 (ongoing)
5	M	67	metachron	cisplatin, fluorouracil	lung, liver	4	1.8/0.7/0.7/5.8	1/1/1/5	21.9/22.8/25.3/14.3	7.3
6	M	52	synchron	cisplatin, fluorouracil	lung	1	2.7	2	20.9	6.3
7	M	71	metachron	NOS	lymph node	1	1.4	5	15.4	14.7
8	M	63	metachron	cisplatin, fluorouracil	liver	1	6.8	7	20.0	3.3
9	M	77	metachron	cisplatin, fluorouracil	lymph node	2	2.2/2.0	1/1	20.1/19.3	10.1
10	M	63	metachron	etoposid, cisplatin, fluorouracil	liver	5	3.4/2.7/1.2/0.9/1.9	2/1/1/1/2	21.2/17.1/22.5/22.7/17.8	4.7
11	M	59	synchron	NOS	lung	2	1.1/0.9	1/1	22.2/15.7	21.7

All patients underwent either surgery or irradiation of the primary tumor prior to local ablation.

Patient No 1 and No 9 received palliative chemotherapy in the time between interstitial high-dose-rate brachytherapy (HDR IBT = IBT) and progression. Furthermore, patient No 9 was treated with RFA of the lung 3 months after IBT

IBT – interstitial brachytherapy; NOS – not otherwise specified

Study design and statistical analysis

Primary endpoint was local tumor control; secondary endpoints were safety, overall survival, and progression-free survival. The results were analyzed in a non-randomized and retrospective approach. Local tumor control (LTC), overall survival (OS), and progression-free survival (PFS) were evaluated using the Kaplan-Meier method with SPSS (IBM Corp. released 2013; IBM SPSS Statistics for Windows, version 22.0. Armonk, NY, IBM Corp). Safety was evaluated descriptively.

Interventional technique and irradiation

The applied methodology has been described in detail elsewhere [17,18]. In short, under guidance of a fluoroscopy-CT (Toshiba, Aquilion, Japan) or real-time MRI at 1.0 T (Panorama 1.0 T, open MR system, Philips Health-care), 18-gauge needle were placed into target lesions. Subsequently, a flexible 6F catheter sheath (Radifocus, Terumo™, Tokyo, Japan) was inserted over a stiff angiography guide wire (Amplatz, Boston Scientific, Marlborough, USA) using Seldinger’s-technique, followed by the placement of a 6F afterloading catheter (Afterloadingkatheter, Primed® Medizintechnik GmbH, Halberstadt, Germany), which ends were secured to the skin with a suture and covered with sterile bandages. The described procedure was performed under a local anesthesia (lidocaine), sedation (midazolam), and analgesia (fentanyl). After catheter positioning, a contrast-enhanced CT in breath-holding technique or a gadolinium-based MRI scan were obtained to confirm correct catheter positioning and for the purpose of treatment planning. On the acquired images, the target volume was outlined precisely as gross tumor volume (GTV), the clinical target volume (CTV), and adjacent organs at risk (OAR) were marked by the interventional radiologist and the radiooncologist. Treatment planning was performed using Oncentra (Oncentra ® Brachy treatment planning system, Elekta AB, Stockholm, Sweden). Automatically calculated isodose lines – relative to the CTV – were controlled and adapted slice by slice. All irradiations were applied as a single fraction irradiation using an iridium-192 source, with a nominal activity of 10 Ci. A reference dose of 15-20 Gy was intended in our patients, which was defined as the minimum dose enclosing the CTV completely (D100). Higher doses inside the tumor volume were permitted and not limited. Dose limitations were taken into account independent of adjacent organs at risk, for example gastric or duodenal wall (< 15 Gy/ml). After irradiation, the catheters were removed, and the puncture tracts were sealed using gelfoam or fibrin tissue glue. Figure 1 illustrates the interventional technique and irradiation planning.

Fig. 1

A) Gd-EOB-DTPA enhanced T1w MRI of a patient with liver metastasis from esophageal squamous cell carcinoma and sequential treatment with interstitial high-dose-rate brachytherapy (HDR IBT = IBT). White arrow indicates lesion planned for IBT and black arrow shows characteristic Gd-EOB-DTPA enhancement defect after irradiation of a metastases 2 weeks before; B) Planning MRI with marked target lesion (red line), isodose lines, and catheters; C) 3 months follow-up: white arrow indicate lesion treated with Gd-EOB-DTPA enhancement defect and black arrow indicate first treated lesion with constant Gd-EOBDTPA enhancement defect after IBT

Follow-up

Clinical, laboratory, and imaging follow-up (contrast enhanced whole body CT and Gb-EOB-DTPA enhanced MRI of the liver – in case of treated hepatic metastases) was performed every three months after treatment. Local tumor control and PFS were assessed by employing RECIST criteria (RECIST version 1.1). Overall survival was calculated from the day of ablation to death. Adverse events were defined according to the Common Terminology Criteria for Adverse Events (CTCAE) version 4.03.

Results

The median diameter of 21 metastases was 2.2 cm (range: 0.7-6.8 cm). A mean of 2.3 catheters per lesion (range: 1-7) was employed to achieve full coverage of the target lesion. Ten patients were treated in one session. One patient received 2 sessions: patient No 5 developed a solitary liver metastasis 4 months after first IBT of pulmonary and nodal lesions, and thereupon received a local treatment of the liver. The intended minimum tumor dose (D100) was 15-20 Gy, depending on localization: retroperitoneal lymph node and adrenal gland were intended to treat with 15 Gy, whereas 20 Gy was prescribed for liver and lung malignancies. The median D100 administered was 20.1 Gy (range: 10-25 Gy). In some cases, the D100 had to be lowered to protect adjacent risk structures. Full dose coverage of the GTV was achieved in 5 lung lesions and 6 liver lesions (20 Gy, respectively), and a minimum of 15 Gy was reached in 4 lymph node metastases (including retroperitoneal space) as well as in the lesion of the adrenal gland. During the treatment, no adjacent OAR were irradiated in excess of critical value. The mean irradiation time was 28 min (range: 11-68 min). The mean hospital stay of the patients was 4.4 days (range: 2-7 days). None of the patients experienced grade III+ adverse events requiring interventions, surgery, or hospitalization. However, 4 patients received peri-interventional intravenous antibiosis (ciproflaxacin and metronidazole) to reduce the risk of a possible infection, e.g. due to treatment of a central liver lesion. The median follow-up time was 6.3 months (range: 3-21.8 months). Three patients displayed local recurrence of the target lesion in the timespan of 3-7 months after IBT, resulting in a local tumor control of 85.7% in the Kaplan-Meier analysis (Figure 2A). The recurrent lesions were 2 lung lesions and 1 liver metastasis; these lesions were covered with a minimum tumor dose of ≥ 20 Gy at time of treatment. The progression-free interval for all patients ranged from 1.3 to 13 months, with a median of 3.4 months (Figure 2B). During the follow-up period, all patients displayed a progressive systemic disease: 3 patients showed intrahepatic progression (27.3%), 3 patients presented pulmonary progression (27.3%), and 5 patients demonstrated progression in various locations (45.4%; i.e. lymph node, retroperitoneal space, bone). At the date of censoring, one patient of the analyzed population was still alive (Patient No. 4 received treatment in June 2017). The median OS of the 10 remaining patients after IBT was 13.7 months (range: 5.6-25.7 months, Figure 2C). Median survival after recurrence was 6 months (range: 1-22 months, Figure 2D).

Fig. 2

Kaplan-Meier curves show A) local tumor control and B) progression-free survival of patients with squamous cell carcinoma metastases ablated with interstitial high-dose-rate brachytherapy. Overall survival and overall survival after tumor progression of the same patients is depicted in C), and D) Censoring is indicated by crosses

Discussion

Within 3 years after curative surgery, up to 88.9% of patients with EC develop metastases, with a median disease-free interval of 1 year after resection [4,5,6,7]. The post-recurrence survival is extremely poor, with a reported median survival of approximately 3-7 months [8,19,20]. Therapy options are limited and according to the ESMO guidelines, a recommendation can be neither made for a first- nor for a second-line palliative chemotherapy in stage IV patients with SCC [11]. More recently, a phase-3, double-blind, placebo-controlled randomized trial with 450 patients failed to show a benefit of gefitinib on overall survival [20].

Whereas surgical resection is the method of choice in oligometastatic colorectal liver metastases, evidence for surgical resection of EC metastases is scarce [21,22]. Nevertheless, in metastatic EC, long-term survivors have been reported after resection of liver metastases in a curative intent [23]. Moreover, in 2017, van Daele et al. retrospectively analyzed the outcome of 12 stage IV patients with EC, after a multimodal and aggressive treatment including surgery [24]. Furthermore, after a median follow-up of 22 months (range: 8-50), 50% of the surgical patients were still alive. These findings suggest that highly selected candidates benefit from an aggressive curative approach, even in stage IV patients.

However, surgical resection is available in a limited number of cases (for instance in colorectal cancer), a curative resection of liver metastases is not possible in approximately 80% of the cases [21] but if possible, it is also linked to surgery-associated morbidity and mortality, regarding the extent of resection and the remaining functioning liver tissue. It results in prolonged stay in the hospital, for instance in the study mentioned above, the median post-operative hospital stay was 15 days (range: 11-52 days).

In contrast, image-guided IBT provides a safe and minimal invasive approach. In the literature for patients undergoing local ablation of liver lesions or metastases of the retroperitoneal space, grade III-IV adverse events (i.e. bleeding, requiring angiographic embolization) occurred in up to 3%, grade I and II toxicities (e.g. nausea, emesis, unspecified abdominal pain) were reported in up to 29% [18,25]. In the study herein, we did not report any severe adverse event (grade III+) requiring invasive intervention. The mean hospital stay was 4.4 days. In general, patients tolerated the treatment well and could be discharged earlier, but due to the risk of occult bleeding, an observation of at least 48 hours after ablation was considered necessary.

To our knowledge, there is a limited number of studies investigating the efficacy and outcome of patients with metastatic EC treated with local ablation. Matsui et al. retrospectively evaluated LTC of 21 patients, with a total of 31 pulmonary metastases (mean size, 1.7 cm) treated with percutaneous radiofrequency ablation (RFA) [26]. The authors reported LTC rate of 74.2% after a median interval of 4.8 months post-RFA. Baba et al. showed a better LTC of 83% at 12 months after RFA of pulmonary SCC metastases [27].

In contrast, IBT has primarily been evaluated in metastatic colorectal cancer and in hepatocellular carcinoma (HCC), demonstrating LTC rates of 88.3% after 12 months for colorectal lesions and up to 95% for HCC [15,17,28]. Moreover, in metastatic malignant melanoma, the LTC rate was reported to be 90% after a median follow-up period of 5 months [14]. Furthermore, for metastases of gastric or esophageal adenocarcinoma, Geisel et al. showed LTC rate of 100% over a median follow-up of 6.1 months post IBT [16]. In our study, we report a local tumor control of 85.7% after a median follow-up of 6.3 months. The reported difference might be due to very small patients’ population and relatively short follow-up period. Therefore, it can be assumed that our findings go in line with the existing literature. Moreover, our findings correspond to the results of RFA studies mentioned above, even providing a better LTC compared to the investigation of Matsui et al. However, RFA has well known technical limitations leading to a possible incomplete ablation, including a large tumor mass (maximal tumor diameter of 5 cm) and major vessels close to the target volume inducing a potential cooling effect. Additionally, adverse events can occur due to the vicinity to critical heat sensitive organs (e.g. bile duct, ureter, liver hilum). IBT in contrast is independent of these restrictions.

To our knowledge, there are only a few studies investigating the use of stereotactic body radiation therapy (SBRT) in the treatment of visceral or pulmonary metastases of EC: two case reports combining SBRT and palliative chemotherapy [29,30], and two studies investigating the effect of SBRT in oligometastatic disease and in solitary/ limited number of nodal metastases, both studies including lesions of any primary site, i.e. 2 and 1 patients with EC, respectively [31,32].

A widespread systemic progression is known to be the major limiting factor for survival, concluding that our finding of a median PFS of 3.4 months emphasizes the poor overall survival of patients with metastasized EC. Consistently, Geisel et al. reported a median PFS of 3.5 months in patients with metastatic esophageal adenocarcinoma after IBT [16].

In our study, we report a median overall survival of 13.7 months after IBT, with a range of 5.6-25.7 months. These findings underline that the impact of local ablation on overall survival is not yet clarified, especially considering the fact that in metastasized SCC, chemotherapeutic options are missing. After recurrence, the survival was poor with a median of 6 months corresponding to the findings in the literature [8]. Nevertheless, we also report one long-term survivor with 25 months. After an aggressive multimodal approach including surgery, van Daele et al. reported a median OS of 22 months indicating possible long-term survival of selected stage IV patients [24]. To identify appropriate candidates that might benefit from local ablation with the intent to extend survival, a prospective trial is needed.

Therefore, the limitations of the study include its retrospective nature and the low number of patients as well as relatively short follow-up. However, to our knowledge, there is little data regarding local ablation of metastatic EC and despite its limitations, the results of this study demonstrate that IBT can be safely and effectively used in the local control of metastasized SCC. Moreover, together with the findings of van Daele et al., this investigation provides an indication that a more aggressive approach could improve the overall survival of highly selected stage IV patients, with an emphasis on the advantage that IBT is a well-tolerated procedure with few side effects.

Conclusions

We conclude that high-dose-rate brachytherapy is a safe and well-tolerated treatment in the local tumor control of patients with metastasized squamous cell carcinoma.

Disclosure

Authors report no conflict of interest.