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Literature DB >> 30478162

Comparative Genomics of Serial Candida glabrata Isolates and the Rapid Acquisition of Echinocandin Resistance during Therapy.

Amelia E Barber¹, Michael Weber^1,2,3, Kerstin Kaerger¹, Jörg Linde^2,3, Hanna Gölz⁴, Daniel Duerschmied^5,6, Antonie Markert⁶, Reinhard Guthke², Grit Walther¹, Oliver Kurzai^7,8.

Abstract

The opportunistic pathogen Candida glabrata shows a concerning increase in drug resistance. Here, we present the analysis of two serial bloodstream isolates, obtained 12 days apart. Both isolates show pan-azole resistance and echinocandin resistance was acquired during the sampling interval. Genome sequencing identified nine nonsynonymous SNVs between the strains, including a S663P substitution in FKS2 and previously undescribed SNVs in MDE1 and FPR1, offering insight into how C. glabrata acquires drug resistance and adapts to a human host.

Entities: Chemical Mutation Species

Keywords: Candidazzm321990; Candida glabratazzm321990; candidiasis; comparative genomics; fungus; resistance

Mesh：

Substances：

Year: 2019 PMID： 30478162 PMCID： PMC6355595 DOI： 10.1128/AAC.01628-18

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

21 in total

Review 1. Tipping the balance both ways: drug resistance and virulence in Candida glabrata.

Authors: Luis A Vale-Silva; Dominique Sanglard
Journal: FEMS Yeast Res Date: 2015-05-15 Impact factor: 2.796

2. VariantAnnotation: a Bioconductor package for exploration and annotation of genetic variants.

Authors: Valerie Obenchain; Michael Lawrence; Vincent Carey; Stephanie Gogarten; Paul Shannon; Martin Morgan
Journal: Bioinformatics Date: 2014-03-28 Impact factor: 6.937

3. Proteomics of drug resistance in Candida glabrata biofilms.

Authors: C Jayampath Seneviratne; Yu Wang; Lijian Jin; Y Abiko; Lakshman P Samaranayake
Journal: Proteomics Date: 2010-04 Impact factor: 3.984

4. Multilocus sequence typing of Candida glabrata reveals geographically enriched clades.

Authors: Andrew R Dodgson; Claude Pujol; David W Denning; David R Soll; Andrew J Fox
Journal: J Clin Microbiol Date: 2003-12 Impact factor: 5.948

5. Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations.

Authors: Barbara D Alexander; Melissa D Johnson; Christopher D Pfeiffer; Cristina Jiménez-Ortigosa; Jelena Catania; Rachel Booker; Mariana Castanheira; Shawn A Messer; David S Perlin; Michael A Pfaller
Journal: Clin Infect Dis Date: 2013-03-13 Impact factor: 9.079

6. Role of FKS Mutations in Candida glabrata: MIC values, echinocandin resistance, and multidrug resistance.

Authors: Cau D Pham; Naureen Iqbal; Carol B Bolden; Randall J Kuykendall; Lee H Harrison; Monica M Farley; William Schaffner; Zintars G Beldavs; Tom M Chiller; Benjamin J Park; Angela A Cleveland; Shawn R Lockhart
Journal: Antimicrob Agents Chemother Date: 2014-06-02 Impact factor: 5.191

7. Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin.

Authors: Guillaume Lesage; Anne-Marie Sdicu; Patrice Ménard; Jesse Shapiro; Shamiza Hussein; Howard Bussey
Journal: Genetics Date: 2004-05 Impact factor: 4.562

8. Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata.

Authors: Sheena D Singh-Babak; Tomas Babak; Stephanie Diezmann; Jessica A Hill; Jinglin Lucy Xie; Ying-Lien Chen; Susan M Poutanen; Robert P Rennie; Joseph Heitman; Leah E Cowen
Journal: PLoS Pathog Date: 2012-05-17 Impact factor: 6.823

9. Declining incidence of candidemia and the shifting epidemiology of Candida resistance in two US metropolitan areas, 2008-2013: results from population-based surveillance.

Authors: Angela Ahlquist Cleveland; Lee H Harrison; Monica M Farley; Rosemary Hollick; Betsy Stein; Tom M Chiller; Shawn R Lockhart; Benjamin J Park
Journal: PLoS One Date: 2015-03-30 Impact factor: 3.240

10. Comparative genomics of emerging pathogens in the Candida glabrata clade.

Authors: Toni Gabaldón; Tiphaine Martin; Marina Marcet-Houben; Pascal Durrens; Monique Bolotin-Fukuhara; Olivier Lespinet; Sylvie Arnaise; Stéphanie Boisnard; Gabriela Aguileta; Ralitsa Atanasova; Christiane Bouchier; Arnaud Couloux; Sophie Creno; Jose Almeida Cruz; Hugo Devillers; Adela Enache-Angoulvant; Juliette Guitard; Laure Jaouen; Laurence Ma; Christian Marck; Cécile Neuvéglise; Eric Pelletier; Amélie Pinard; Julie Poulain; Julien Recoquillay; Eric Westhof; Patrick Wincker; Bernard Dujon; Christophe Hennequin; Cécile Fairhead
Journal: BMC Genomics Date: 2013-09-14 Impact factor: 3.969

6 in total

Review 1. Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens.

Authors: Miquel Àngel Schikora-Tamarit; Toni Gabaldón
Journal: Biochem Soc Trans Date: 2022-06-30 Impact factor: 4.919

2. Antifungal Susceptibility of Clinical Yeast Isolates from a Large Canadian Reference Laboratory and Application of Whole-Genome Sequence Analysis To Elucidate Mechanisms of Acquired Resistance.

Authors: Lisa R McTaggart; Ana Cabrera; Kirby Cronin; Julianne V Kus
Journal: Antimicrob Agents Chemother Date: 2020-08-20 Impact factor: 5.191

3. Population genetics and microevolution of clinical Candida glabrata reveals recombinant sequence types and hyper-variation within mitochondrial genomes, virulence genes, and drug targets.

Authors: Nicolas Helmstetter; Aleksandra D Chybowska; Christopher Delaney; Alessandra Da Silva Dantas; Hugh Gifford; Theresa Wacker; Carol Munro; Adilia Warris; Brian Jones; Christina A Cuomo; Duncan Wilson; Gordon Ramage; Rhys A Farrer
Journal: Genetics Date: 2022-05-05 Impact factor: 4.402