Literature DB >> 30476497

Modeling Human Digestive Diseases With CRISPR-Cas9-Modified Organoids.

Masayuki Fujii1, Hans Clevers2, Toshiro Sato3.   

Abstract

Insights into the stem cell niche have allowed researchers to cultivate adult tissue stem cells as organoids that display structural and phenotypic features of healthy and diseased epithelial tissues. Organoids derived from patients' tissues are used as models of disease and to test drugs. CRISPR-Cas9 technology can be used to genetically engineer organoids for studies of monogenic diseases and cancer. We review the derivation of organoids from human gastrointestinal tissues and how CRISPR-Cas9 technology can be used to study these organoids. We discuss burgeoning technologies that are broadening our understanding of diseases of the digestive system.
Copyright © 2019 AGA Institute. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Colorectal Cancer; Gastric Cancer; Inflammatory Bowel Disease; Pancreatic Cancer

Mesh：

Year:  2018        PMID： 30476497     DOI： 10.1053/j.gastro.2018.11.048

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  37 in total

1.  The Synthetic Small Molecule FL3 Combats Intestinal Tumorigenesis via Axin1-Mediated Inhibition of Wnt/β-Catenin Signaling.

Authors:  Dakota N Jackson; Kibrom M Alula; Yaritza Delgado-Deida; Redouane Tabti; Kevin Turner; Xuan Wang; K Venuprasad; Rhonda F Souza; Laurent Désaubry; Arianne L Theiss
Journal:  Cancer Res       Date:  2020-07-14       Impact factor: 12.701

2.  Multicellular Systems to Translate Somatic Cell Genome Editors to Humans.

Authors:  Victor Hernandez-Gordillo; Thomas Caleb Casolaro; Mo R Ebrahimkhani; Samira Kiani
Journal:  Curr Opin Biomed Eng       Date:  2020-10-10

Review 3.  [Development of CRISPR technology and its application in bone and cartilage tissue engineering].

Authors:  Guo Chen; Du Cheng; Bin Chen
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2019-12-30

Review 4.  Understanding immune-microbiota interactions in the intestine.

Authors:  Philip P Ahern; Kevin J Maloy
Journal:  Immunology       Date:  2019-11-27       Impact factor: 7.397

5.  Establishing a living biobank of patient-derived organoids of intraductal papillary mucinous neoplasms of the pancreas.

Authors:  Francisca Beato; Dayana Reverón; Kaleena B Dezsi; Antonio Ortiz; Joseph O Johnson; Dung-Tsa Chen; Karla Ali; Sean J Yoder; Daniel Jeong; Mokenge Malafa; Pamela Hodul; Kun Jiang; Barbara A Centeno; Mahmoud A Abdalah; Jodi A Balasi; Alexandra F Tassielli; Bhaswati Sarcar; Jamie K Teer; Gina M DeNicola; Jennifer B Permuth; Jason B Fleming
Journal:  Lab Invest       Date:  2020-10-09       Impact factor: 5.662

Review 6.  Research on CRISPR/system in major cancers and its potential in cancer treatments.

Authors:  Z Liu; Z Liao; Y Chen; L Zhou; W Huangting; H Xiao
Journal:  Clin Transl Oncol       Date:  2020-07-15       Impact factor: 3.405

7.  In vitro models of the human endometrium: evolution and application for women's health.

Authors:  Harriet C Fitzgerald; Danny J Schust; Thomas E Spencer
Journal:  Biol Reprod       Date:  2021-02-11       Impact factor: 4.285

Review 8.  Organoids for the Study of Liver Cancer.

Authors:  Haichuan Wang; Diego F Calvisi; Xin Chen
Journal:  Semin Liver Dis       Date:  2021-02-09       Impact factor: 6.115

9.  A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation.

Authors:  Yuan-Hung Lo; Kevin S Kolahi; Yuhong Du; Chiung-Ying Chang; Andrey Krokhotin; Ajay Nair; Walter D Sobba; Kasper Karlsson; Sunny J Jones; Teri A Longacre; Amanda T Mah; Bahar Tercan; Alexandra Sockell; Hang Xu; Jose A Seoane; Jin Chen; Ilya Shmulevich; Jonathan S Weissman; Christina Curtis; Andrea Califano; Haian Fu; Gerald R Crabtree; Calvin J Kuo
Journal:  Cancer Discov       Date:  2021-01-15       Impact factor: 39.397

Review 10.  In vitro models of intestinal epithelium: Toward bioengineered systems.

Authors:  Justine Creff; Laurent Malaquin; Arnaud Besson
Journal:  J Tissue Eng       Date:  2021-02-01       Impact factor: 7.813
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