Susan L Hughes1,2,3, Lisa Tussing-Humphreys1,4,5, Linda Schiffer1, Renae Smith-Ray1,6, David X Marquez1,2,7, Andrew D DeMott1,2, Michael L Berbaum1,8, Marian L Fitzgibbon1,4,9. 1. Institute for Health Research and Policy, School of Public Health. 2. Center for Research on Health and Aging. 3. Division of Community Health Sciences, University of Illinois at Chicago. 4. University of Illinois Cancer Center, Chicago. 5. Department of Medicine, University of Illinois at Chicago. 6. Health Analytics, Research and Reporting, Walgreen Co., Deerfield, Illinois. 7. Department of Kinesiology and Nutrition. 8. Division of Epidemiology and Biostatistics, University of Illinois at Chicago. 9. Department of Pediatrics, University of Illinois at Chicago.
Abstract
BACKGROUND AND OBJECTIVES: We compared the effectiveness of standard Fit &; Strong! (F&S!; targets physical activity [PA]) to Fit &; Strong! Plus (F&S! Plus; targets PA and dietary weight loss) on weight, diet quality, and PA outcomes. RESEARCH DESIGN AND METHODS: We randomly assigned 413 overweight older adults with OA to the F&S! or F&S! Plus programs and assessed outcomes at 2 and 6 months. RESULTS: The F&S! Plus group lost -2.0 ± 0.2 kg (mean ± SE, 2% of starting weight) at 2 months that was maintained at 6 months. Two- and 6-month BMI and waist circumference improved significantly in the F&S! Plus group (p < .001). Diet quality at 2 months showed greater improvement in the F&S! Plus group: 4.6 ± 0.7 versus 2.0 ± 0.7, p = .006, with no significant difference between groups at 6 months. The F&S! Plus group differentially improved on PA engagement at 2 months and at 2 and 6 months in joint pain (6-month mean ± SE: -1.5 ± 0.3 vs -0.6 ± 0.3, p = .02), function (-4.7 ± 0.9 vs -1.5 ± 0.9, p = .01), and 6-min walk test (29.5 ± 5.1 m vs 14.1 ± 5.2 m, p = .04). DISCUSSION AND IMPLICATIONS: Adding a dietary weight loss component to F&S! achieved weight and waist circumference benefits that were maintained at 6 months. Importantly, the weight loss was accompanied by clinically meaningful improvements in OA symptoms and mobility. Future work should investigate minimum thresholds for weight reduction that improve long-term function in this population.
RCT Entities:
BACKGROUND AND OBJECTIVES: We compared the effectiveness of standard Fit & Strong! (F&S!; targets physical activity [PA]) to Fit & Strong! Plus (F&S! Plus; targets PA and dietary weight loss) on weight, diet quality, and PA outcomes. RESEARCH DESIGN AND METHODS: We randomly assigned 413 overweight older adults with OA to the F&S! or F&S! Plus programs and assessed outcomes at 2 and 6 months. RESULTS: The F&S! Plus group lost -2.0 ± 0.2 kg (mean ± SE, 2% of starting weight) at 2 months that was maintained at 6 months. Two- and 6-month BMI and waist circumference improved significantly in the F&S! Plus group (p < .001). Diet quality at 2 months showed greater improvement in the F&S! Plus group: 4.6 ± 0.7 versus 2.0 ± 0.7, p = .006, with no significant difference between groups at 6 months. The F&S! Plus group differentially improved on PA engagement at 2 months and at 2 and 6 months in joint pain (6-month mean ± SE: -1.5 ± 0.3 vs -0.6 ± 0.3, p = .02), function (-4.7 ± 0.9 vs -1.5 ± 0.9, p = .01), and 6-min walk test (29.5 ± 5.1 m vs 14.1 ± 5.2 m, p = .04). DISCUSSION AND IMPLICATIONS: Adding a dietary weight loss component to F&S! achieved weight and waist circumference benefits that were maintained at 6 months. Importantly, the weight loss was accompanied by clinically meaningful improvements in OA symptoms and mobility. Future work should investigate minimum thresholds for weight reduction that improve long-term function in this population.
Authors: Dennis T Villareal; Suresh Chode; Nehu Parimi; David R Sinacore; Tiffany Hilton; Reina Armamento-Villareal; Nicola Napoli; Clifford Qualls; Krupa Shah Journal: N Engl J Med Date: 2011-03-31 Impact factor: 91.245
Authors: Renae L Smith-Ray; Marian L Fitzgibbon; Lisa Tussing-Humphreys; Linda Schiffer; Amy Shah; Gail M Huber; Carol Braunschweig; Richard T Campbell; Susan L Hughes Journal: Contemp Clin Trials Date: 2013-12-05 Impact factor: 2.226
Authors: Sara Wilcox; Bruce McClenaghan; Patricia A Sharpe; Meghan Baruth; Jennifer M Hootman; Katherine Leith; Marsha Dowda Journal: Am J Prev Med Date: 2014-11-06 Impact factor: 5.043
Authors: Teresa T Fung; An Pan; Tao Hou; Stephanie E Chiuve; Deidre K Tobias; Dariush Mozaffarian; Walter C Willett; Frank B Hu Journal: J Nutr Date: 2015-06-17 Impact factor: 4.798
Authors: Susan L Hughes; Rachel B Seymour; Richard T Campbell; Gail Huber; Naomi Pollak; Leena Sharma; Pankaja Desai Journal: Gerontologist Date: 2006-12
Authors: Stephen P Messier; Richard F Loeser; Gary D Miller; Timothy M Morgan; W Jack Rejeski; Mary Ann Sevick; Walter H Ettinger; Marco Pahor; Jeff D Williamson Journal: Arthritis Rheum Date: 2004-05
Authors: Stephen P Messier; Shannon L Mihalko; Claudine Legault; Gary D Miller; Barbara J Nicklas; Paul DeVita; Daniel P Beavers; David J Hunter; Mary F Lyles; Felix Eckstein; Jeff D Williamson; J Jeffery Carr; Ali Guermazi; Richard F Loeser Journal: JAMA Date: 2013-09-25 Impact factor: 56.272
Authors: Jennifer C Sanchez-Flack; Lisa Tussing-Humphreys; Melissa Lamar; Giamilla Fantuzzi; Linda Schiffer; Lara Blumstein; Andrew McLeod; Roxanne Dakers; Desmona Strahan; Leo Restrepo; Nefertiti Oji Njideka Hemphill; Leilah Siegel; Mirjana Antonic; Marian Fitzgibbon Journal: Prev Med Rep Date: 2020-12-31
Authors: Teresa Schering; Linda Schiffer; Andrew McLeod; Andrew DeMott; Susan Hughes; Marian L Fitzgibbon; Lisa Tussing-Humphreys Journal: Nutr Healthy Aging Date: 2021-01-20
Authors: Lisa Tussing-Humphreys; Melissa Lamar; Andrew McLeod; Linda Schiffer; Lara Blumstein; Roxanne Dakers; Aimee Karstens; Nefertiti Oji Njideka Hemphill; Desmona Strahan; Leilah Siegel; Jennifer Sanchez Flack; Mirjana Antonic; Leo Restrepo; Michael Berbaum; Marian Fitzgibbon Journal: Prev Med Rep Date: 2022-08-19
Authors: Andrew McLeod; Linda Schiffer; Karla Castellanos; Andrew DeMott; Sarah Olender; Marian Fitzgibbon; Susan Hughes; Giamila Fantuzzi; Lisa Tussing-Humphreys Journal: Nutrients Date: 2020-10-28 Impact factor: 5.717
Authors: Marian L Fitzgibbon; Lisa Tussing-Humphreys; Linda Schiffer; Renae Smith-Ray; David X Marquez; Andrew D DeMott; Michael L Berbaum; Susan L Hughes Journal: Prev Med Date: 2020-10-03 Impact factor: 4.018