Literature DB >> 30472225

New and Old Biomarkers for Diagnosis and Management of Chronic Hepatitis B Virus Infection.

Carla S Coffin1, Kali Zhou2, Norah A Terrault3.   

Abstract

Tests to detect the presence and activity of hepatitis B virus (HBV) are the cornerstones of diagnosis and management. Assays that detect or measure serum levels of HB surface antigen, HB surface antibody, and HB core antibody are used to identify patients with exposure to HBV, whereas other tests provide information on the level of virus replication, presence of specific variants, and presence of virus reservoirs. Newer diagnostic tests, used only in research settings so far, aim to quantify levels of intrahepatic HBV replication. Other tests have been developed to detect HBV infection in resource-limited settings. We review point-of-care tests (essential in global screening efforts), standard diagnostic tests used in routine clinical management, and newer tests that might be used in clinical trials of agents designed to cure HBV infection.
Copyright © 2019 AGA Institute. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  HBV RNA; HBsAg; Point-of-Care; Quantitative

Mesh：

Substances：

Year:  2018        PMID： 30472225      PMCID： PMC6433165          DOI： 10.1053/j.gastro.2018.11.037

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  22 in total

1.  Prevalence and molecular characterization of occult hepatitis B virus in pregnant women from Gondar, Ethiopia.

Authors:  Vanessa Meier-Stephenson; Tekalign Deressa; Meaza Genetu; Debasu Damtie; Sheila Braun; Kevin Fonseca; Mark G Swain; Guido van Marle; Carla S Coffin
Journal:  Can Liver J       Date:  2020-11-17

Review 2.  A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook.

Authors:  Anna Kramvis; Kyong-Mi Chang; Maura Dandri; Patrizia Farci; Dieter Glebe; Jianming Hu; Harry L A Janssen; Daryl T Y Lau; Capucine Penicaud; Teresa Pollicino; Barbara Testoni; Florian Van Bömmel; Ourania Andrisani; Maria Beumont-Mauviel; Timothy M Block; Henry L Y Chan; Gavin A Cloherty; William E Delaney; Anna Maria Geretti; Adam Gehring; Kathy Jackson; Oliver Lenz; Mala K Maini; Veronica Miller; Ulrike Protzer; Jenny C Yang; Man-Fung Yuen; Fabien Zoulim; Peter A Revill
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2022-07-20       Impact factor: 73.082

3.  KASL clinical practice guidelines for management of chronic hepatitis B.

Authors: 
Journal:  Clin Mol Hepatol       Date:  2022-04-01

Review 4.  Use of HBsAg quantification in the natural history and treatment of chronic hepatitis B.

Authors:  Lung-Yi Mak; Wai-Kay Seto; James Fung; Man-Fung Yuen
Journal:  Hepatol Int       Date:  2019-11-19       Impact factor: 6.047

5.  Rapidly decreased HBV RNA predicts responses of pegylated interferons in HBeAg-positive patients: a longitudinal cohort study.

Authors:  Min Zhang; Guangdi Li; Jia Shang; Chen Pan; Minxiang Zhang; Zhibiao Yin; Qing Xie; Yanzhong Peng; Qing Mao; Xinqiang Xiao; Yongfang Jiang; Kaizhong Luo; Yun Xu; Hai Ding; Wenzhou Fan; Vidaurre Diego; Mahmoud Reza Pourkarim; Erik De Clercq; Guiqiang Wang; Guozhong Gong
Journal:  Hepatol Int       Date:  2020-02-25       Impact factor: 6.047

Review 6.  Hepatitis B and Pregnancy: Virologic and Immunologic Characteristics.

Authors:  Shivali S Joshi; Carla S Coffin
Journal:  Hepatol Commun       Date:  2020-01-02

7.  Clinical Implications of Serum Hepatitis B Virus Pregenomic RNA Kinetics in Chronic Hepatitis B Patients Receiving Antiviral Treatment and Those Achieving HBsAg Loss.

Authors:  I-Chin Wu; Wen-Chun Liu; Yen-Cheng Chiu; Hung-Chih Chiu; Pin-Nan Cheng; Ting-Tsung Chang
Journal:  Microorganisms       Date:  2021-05-26

8.  Hepatitis B and HIV-1 2019 IAS Cure Forum: lessons and benefits from interdisciplinary research.

Authors:  M Paximadis; S Perez Patrigeon; R Rajasuriar; R Tatoud; E Scully; P Arbuthnot
Journal:  J Virus Erad       Date:  2019-11-04

9.  Hepatitis B virus seroepidemiology data for Africa: Modelling intervention strategies based on a systematic review and meta-analysis.

Authors:  Anna L McNaughton; José Lourenço; Phillip Armand Bester; Jolynne Mokaya; Sheila F Lumley; Uri Obolski; Donall Forde; Tongai G Maponga; Kenneth R Katumba; Dominique Goedhals; Sunetra Gupta; Janet Seeley; Robert Newton; Ponsiano Ocama; Philippa C Matthews
Journal:  PLoS Med       Date:  2020-04-21       Impact factor: 11.613

10.  Single-nucleotide polymorphism of rs7944135 (macrophage-expressed gene 1) is associated with hepatitis B surface antigen seroclearance in chronic hepatitis B infection: A cohort study.

Authors:  Lalu Muhammad Irham; Henry Sung-Ching Wong; Dyah Aryani Perwitasari; Wan-Hsuan Chou; Hwai-I Yang; Wei-Chiao Chang
Journal:  Medicine (Baltimore)       Date:  2019-12       Impact factor: 1.889
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