Literature DB >> 30471676

Recent advances of the Povarov reaction in medicinal chemistry.

Ouldouz Ghashghaei1, Carme Masdeu2, Concepción Alonso2, Francisco Palacios3, Rodolfo Lavilla4.   

Abstract

The Povarov multicomponent reaction consists on the condensation of an aniline, an aldehyde, and an activated olefin to generate a tetrahydroquinoline adduct with 3 diversity points. Hereby, we report the main features of this transformation and its uses in medicinal chemistry. Relevant examples of the impact of Povarov adducts in different therapeutic areas are provided.
Copyright © 2018 Elsevier Ltd. All rights reserved.

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Year:  2018        PMID： 30471676     DOI： 10.1016/j.ddtec.2018.08.004

Source DB:  PubMed          Journal:  Drug Discov Today Technol        ISSN： 1740-6749


  6 in total

Review 1.  On-resin multicomponent protocols for biopolymer assembly and derivatization.

Authors:  Daniel G Rivera; Manuel G Ricardo; Aldrin V Vasco; Ludger A Wessjohann; Erik V Van der Eycken
Journal:  Nat Protoc       Date:  2021-01-20       Impact factor: 13.491

2.  Oxone promoted dehydrogenative Povarov cyclization of N-aryl glycine derivatives: an approach towards quinoline fused lactones and lactams.

Authors:  Devidas A More; Ganesh H Shinde; Aslam C Shaikh; M Muthukrishnan
Journal:  RSC Adv       Date:  2019-09-25       Impact factor: 4.036

Review 3.  Synthetic Strategies, Reactivity and Applications of 1,5-Naphthyridines.

Authors:  Maria Fuertes; Carme Masdeu; Endika Martin-Encinas; Asier Selas; Gloria Rubiales; Francisco Palacios; Concepcion Alonso
Journal:  Molecules       Date:  2020-07-16       Impact factor: 4.411

4.  Synthesis of dihydroisoindolo[2,1-a]quinolin-11-ones, their in silico ADMET properties and in vitro antitumor activities.

Authors:  Diego R Merchán-Arenas; Felipe Sojo; Francisco Arvelo; Vladimir V Kouznetsov
Journal:  RSC Adv       Date:  2020-11-19       Impact factor: 4.036

Review 5.  Heterocycle-Based Multicomponent Reactions in Drug Discovery: From Hit Finding to Rational Design.

Authors:  Pau Nadal Rodríguez; Ouldouz Ghashghaei; Andrea Bagán; Carmen Escolano; Rodolfo Lavilla
Journal:  Biomedicines       Date:  2022-06-23

6.  Switch From Pauli-Lowering to LUMO-Lowering Catalysis in Brønsted Acid-Catalyzed Aza-Diels-Alder Reactions.

Authors:  Song Yu; F Matthias Bickelhaupt; Trevor A Hamlin
Journal:  ChemistryOpen       Date:  2021-08       Impact factor: 2.630
  6 in total

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