Abdelaal M Elkamshoushi1, Salma S Omar1, Amr M El Abd2, Seham Z Hassan3, Eman A Sultan4, Eman Abd Elkawy1. 1. Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. 2. Department of Radiodiagnosis and Interventional Radiology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. 3. Department of Medical Physiology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. 4. Department of Community Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Abstract
BACKGROUND: Psoriasis is a common multisystem inflammatory disease with several associated comorbidities. Serological markers to detect associated subclinical atherosclerosis in psoriatic patients are needed. We aimed to study serum endocan levels in psoriasis vulgaris and its relation to severity of psoriasis, systemic inflammation, associated atherosclerosis, obesity, and the possible factors affecting its level in psoriatic patients. METHODS: This study was conducted on 30 moderate-severe psoriasis vulgaris patients and 30 healthy controls. Body mass index, body fat percent, and PASI assessments were done. Serum endocan and tumor necrosis factor-α levels were measured by ELISA. Carotid artery intima-media thickness measurement by high-resolution ultrasound was performed. RESULTS: Psoriasis patients showed significantly higher serum tumor necrosis factor-α and endocan levels (P1 = 0.008, P2 = 0.003). Additionally, there was a statistically significant difference between mean carotid artery intima-media thickness of both groups (P = 0.005). Serum endocan levels positively correlated with PASI score (P = 0.002), tumor necrosis factor-α levels (P < 0.001), mean carotid artery intima-media thickness (P = 0.001), and body mass index (P < 0.001) in the patients group. Additionally, the age of onset of disease negatively correlated with serum endocan (P = 0.003). CONCLUSION: Serum endocan is a promising marker of severity of psoriasis and associated atherosclerosis. Early onset psoriasis is associated with higher serum endocan levels. Body mass index is positively correlated with serum endocan levels. The positive correlation of endocan and tumor necrosis factor-α supports the regulatory effect of the cytokine on endocan production and suggests the role of endocan as an inflammatory marker.
BACKGROUND:Psoriasis is a common multisystem inflammatory disease with several associated comorbidities. Serological markers to detect associated subclinical atherosclerosis in psoriaticpatients are needed. We aimed to study serum endocan levels in psoriasis vulgaris and its relation to severity of psoriasis, systemic inflammation, associated atherosclerosis, obesity, and the possible factors affecting its level in psoriaticpatients. METHODS: This study was conducted on 30 moderate-severe psoriasis vulgarispatients and 30 healthy controls. Body mass index, body fat percent, and PASI assessments were done. Serum endocan and tumor necrosis factor-α levels were measured by ELISA. Carotid artery intima-media thickness measurement by high-resolution ultrasound was performed. RESULTS:Psoriasispatients showed significantly higher serum tumor necrosis factor-α and endocan levels (P1 = 0.008, P2 = 0.003). Additionally, there was a statistically significant difference between mean carotid artery intima-media thickness of both groups (P = 0.005). Serum endocan levels positively correlated with PASI score (P = 0.002), tumor necrosis factor-α levels (P < 0.001), mean carotid artery intima-media thickness (P = 0.001), and body mass index (P < 0.001) in the patients group. Additionally, the age of onset of disease negatively correlated with serum endocan (P = 0.003). CONCLUSION: Serum endocan is a promising marker of severity of psoriasis and associated atherosclerosis. Early onset psoriasis is associated with higher serum endocan levels. Body mass index is positively correlated with serum endocan levels. The positive correlation of endocan and tumor necrosis factor-α supports the regulatory effect of the cytokine on endocan production and suggests the role of endocan as an inflammatory marker.
Authors: Aleksandra Klisić; Nebojša Kavarić; Vesna Spasojević-Kalimanovska; Jelena Kotur-Stevuljević; Ana Ninić Journal: J Med Biochem Date: 2021-01-26 Impact factor: 3.402
Authors: Eman Mostafa Nassef; Hemmat Ahmed Elabd; Basma Mohamed Mohamed Ali El Nagger; Hala Mohamed Elzomor; Hend Gamal Kotb; Seham Sabry; Boshra Ahmed Zaghloul; Asmaa S Hassan; Eman El Sayed Mohamed Journal: Int J Gen Med Date: 2022-08-18
Authors: Fatma M El-Senosy; Rasha Elsayed Mohamed Abd El Aziz; Sammar Ahmed Kasim; Lamia Abdulbary Gad; Donia Ahmed Hassan; Seham Sabry; Ismail Mohamed El Mancy; Taiseer Ahmed Shawky; Ibrahim Ghounim Ramadan Mohamed; Rady Elmonier; Essam Kotb; Abeer Mohammed Abdul-Mohymen Journal: Int J Clin Pract Date: 2022-07-13 Impact factor: 3.149