Nazan Degirmenci1, Bayram Veyseller2, Hasmet Hanagasi3, Basar Bilgic3, Defne Gurbuz4, Ali Toprak5, Orhan Ozturan6. 1. Department of Otorhinolaryngology and Head and Neck Surgery, Bezmialem Vakif University, Istanbul, Turkey. nzndegirmenci@hotmail.com. 2. Department of Otorhinolaryngology and Head and Neck Surgery, Medical Faculty, Acibadem University, Istanbul, Turkey. 3. Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. 4. Department of Radiology, Okmeydani Training and Research Hospital, Istanbul, Turkey. 5. Department of Biostatistics and Medical Informatics, Bezmialem Vakif University, Istanbul, Turkey. 6. Department of Otorhinolaryngology and Head and Neck Surgery, Bezmialem Vakif University, Istanbul, Turkey.
Abstract
PURPOSE: To evaluate the olfactory function and the olfactory bulb (OB) volume changes in Wilson's Disease (WD) patients. METHODS: A prospective, controlled, single-blinded study was planned. 12 patients with WD (Group 1) and 12 healthy subjects (Group 2) were included in the study. Connecticut Chemosensory Clinical Research Center (CCCRC) test was applied to evaluate olfactory functions. OB volumes were measured with a 1.5 T General Electric Signa Excite MRI scanner. RESULTS: There was a significant difference between the CCCRC scores of the two groups (p < 0.05). The difference of the OB volumes of the two groups was insignificant (p > 0.05). CONCLUSIONS: WD patients are likely to experience olfactory dysfunction, so its assessment may be a useful tool to the follow-up care of these patients, although further studies are needed to evaluate correlations in WD evolution.
RCT Entities:
PURPOSE: To evaluate the olfactory function and the olfactory bulb (OB) volume changes in Wilson's Disease (WD) patients. METHODS: A prospective, controlled, single-blinded study was planned. 12 patients with WD (Group 1) and 12 healthy subjects (Group 2) were included in the study. Connecticut Chemosensory Clinical Research Center (CCCRC) test was applied to evaluate olfactory functions. OB volumes were measured with a 1.5 T General Electric Signa Excite MRI scanner. RESULTS: There was a significant difference between the CCCRC scores of the two groups (p < 0.05). The difference of the OB volumes of the two groups was insignificant (p > 0.05). CONCLUSIONS:WDpatients are likely to experience olfactory dysfunction, so its assessment may be a useful tool to the follow-up care of these patients, although further studies are needed to evaluate correlations in WD evolution.
Authors: Bayram Veyseller; Berke Ozucer; Fadlullah Aksoy; Yavuz Selim Yildirim; Defne Gürbüz; Hasan Hüseyin Balikçi; Orhan Ozturan Journal: Am J Rhinol Allergy Date: 2012 May-Jun Impact factor: 2.467
Authors: G C Passali; F Bove; L Vargiu; A R Bentivoglio; R Anzivino; E De Corso; J Galli; M Rigante; M Pandolfini; B Sergi; M Giuliani; F Cianfrone; G Paludetti; A Fasano Journal: Clin Otolaryngol Date: 2017-02-01 Impact factor: 2.597