| Literature DB >> 30465354 |
Qi-Zhang Wang1, Ji-Yuan Liu1, Jian Pan1.
Abstract
Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication of bisphosphonates (BPs) or other targeted agent therapies. MRONJ appears as exposed bone, pus, and swelling in the oral and maxillofacial regions. However, neither surgery nor conservative therapy can eliminate symptoms thoroughly. In addition to BPs, several antiresorptive and antiangiogenic agents, such as denosumab and bevacizumab, as well as targeted agents, such as sunitinib and temsirolimus, can cause osteonecrosis of the jaw according to the literature. This review aims to summarize the research progress on these new drugs.Entities:
Keywords: bevacizumab; bisphosphonates; denosumab; osteonecrosis
Mesh:
Substances:
Year: 2018 PMID: 30465354 PMCID: PMC7041135 DOI: 10.7518/hxkq.2018.05.019
Source DB: PubMed Journal: Hua Xi Kou Qiang Yi Xue Za Zhi ISSN: 1000-1182