Literature DB >> 30458218

Postsynaptic SNARE Proteins: Role in Synaptic Transmission and Plasticity.

María Pilar Madrigal1, Adrián Portalés1, María Pérez SanJuan1, Sandra Jurado2.   

Abstract

Soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) proteins mediate membrane fusion events in eukaryotic cells. Traditionally recognized as major players in regulating presynaptic neurotransmitter release, accumulative evidence over recent years has identified several SNARE proteins implicated in important postsynaptic processes such as neurotransmitter receptor trafficking and synaptic plasticity. Here we analyze the emerging data revealing this novel functional dimension for SNAREs with a focus on the molecular specialization of vesicular recycling and fusion in dendrites compared to those at axon terminals and its impact in synaptic transmission and plasticity.
Copyright © 2018 IBRO. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  neurotransmitter receptor trafficking; postsynaptic SNARE proteins; postsynaptic exocytosis; synaptic plasticity

Mesh:

Substances:

Year:  2018        PMID: 30458218      PMCID: PMC6525081          DOI: 10.1016/j.neuroscience.2018.11.012

Source DB:  PubMed          Journal:  Neuroscience        ISSN: 0306-4522            Impact factor:   3.590


  113 in total

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