Na Li1, Chujie Zeng1, Qipin Qin1, Biaoming Zhang1, Lina Chen1, Zhihui Luo1. 1. Guangxi Key Laboratory of Agricultural Resources Chemistry & Biotechnology, College of Chemistry & Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin, 537000, PR China.
Abstract
AIM: The development of new and efficient antibacterial agents is urgent to overcome emerging antimicrobial resistance. MATERIALS & METHODS: Herein, we have presented a new type of 3D antibacterial system to prompt bacteria to contact with the any plane of nanocomposites. RESULTS: Comparing the antibacterial activity of graphene oxide, reduced graphene oxide and graphene-loaded nanoflower-like nickelous hydroxide (GN/Ni(OH)2) nanocomposites; the GN/Ni(OH)2 showed stronger bactericidal capability toward Gram-negative/-positive bacteria. Moreover, the GN/Ni(OH)2 with low cytotoxicity can promote it as 'green' antimicrobial agents. And, the GN/Ni(OH)2 presented long-term stable antibacterial effectiveness after 2-month storage. The antibacterial mechanisms of GN/Ni(OH)2 were evidenced as the 3D contact and violent damage to the bacterial structure. CONCLUSION: The GN/Ni(OH)2 provides new insights into the antibacterial properties of 3D nanocomposites for effectively fighting pathogen threats in biomedicine and public health.
AIM: The development of new and efficient antibacterial agents is urgent to overcome emerging antimicrobial resistance. MATERIALS & METHODS: Herein, we have presented a new type of 3D antibacterial system to prompt bacteria to contact with the any plane of nanocomposites. RESULTS: Comparing the antibacterial activity of graphene oxide, reduced graphene oxide and graphene-loaded nanoflower-like nickelous hydroxide (GN/Ni(OH)2) nanocomposites; the GN/Ni(OH)2 showed stronger bactericidal capability toward Gram-negative/-positive bacteria. Moreover, the GN/Ni(OH)2 with low cytotoxicity can promote it as 'green' antimicrobial agents. And, the GN/Ni(OH)2 presented long-term stable antibacterial effectiveness after 2-month storage. The antibacterial mechanisms of GN/Ni(OH)2 were evidenced as the 3D contact and violent damage to the bacterial structure. CONCLUSION: The GN/Ni(OH)2 provides new insights into the antibacterial properties of 3D nanocomposites for effectively fighting pathogen threats in biomedicine and public health.
Entities:
Keywords:
3D GN/Ni(OH) ; antibacterial activity; biocompatibility; long-term effectiveness; membrane