| Literature DB >> 30455248 |
Khadidja Yousfi1, Christiane Gaudreau2,3, Pierre A Pilon1,4, Brigitte Lefebvre1, Matthew Walker5, Éric Fournier1, Florence Doualla Bell1, Christine Martineau1,2, Jean Longtin1, Sadjia Bekal6,2.
Abstract
We analyzed 254 Shigella species isolates collected in Québec, Canada, during 2013 and 2014. Overall, 23.6% of isolates showed reduced susceptibility to azithromycin (RSA) encoded by mphA (11.6%), ermB (1.7%), or both genes (86.7%). Shigella strains with RSA were mostly isolated from men who have sex with men (68.8% or higher) from the Montreal region. A complete sequence analysis of six selected plasmids from Shigella sonnei and different serotypes of Shigella flexneri emphasized the role of IS26 in the dissemination of RSA.Entities:
Keywords: IS26 insertion sequence; Shigella spp.; plasmid diversity; reduced susceptibility to azithromycin
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Year: 2019 PMID: 30455248 PMCID: PMC6355565 DOI: 10.1128/AAC.01679-18
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191