Literature DB >> 30455248

Genetic Mechanisms behind the Spread of Reduced Susceptibility to Azithromycin in Shigella Strains Isolated from Men Who Have Sex with Men in Québec, Canada.

Khadidja Yousfi1, Christiane Gaudreau2,3, Pierre A Pilon1,4, Brigitte Lefebvre1, Matthew Walker5, Éric Fournier1, Florence Doualla Bell1, Christine Martineau1,2, Jean Longtin1, Sadjia Bekal6,2.   

Abstract

We analyzed 254 Shigella species isolates collected in Québec, Canada, during 2013 and 2014. Overall, 23.6% of isolates showed reduced susceptibility to azithromycin (RSA) encoded by mphA (11.6%), ermB (1.7%), or both genes (86.7%). Shigella strains with RSA were mostly isolated from men who have sex with men (68.8% or higher) from the Montreal region. A complete sequence analysis of six selected plasmids from Shigella sonnei and different serotypes of Shigella flexneri emphasized the role of IS26 in the dissemination of RSA.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  IS26 insertion sequence; Shigella spp.; plasmid diversity; reduced susceptibility to azithromycin

Mesh:

Substances:

Year:  2019        PMID: 30455248      PMCID: PMC6355565          DOI: 10.1128/AAC.01679-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


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3.  Shigella spp. with reduced azithromycin susceptibility, Quebec, Canada, 2012-2013.

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