| Literature DB >> 30450632 |
Tais Pereira-Veiga1,2, Manuel Abreu3, Diego Robledo4, Xavier Matias-Guiu5,6, María Santacana5, Laura Sánchez7, Juan Cueva8, Patricia Palacios8, Ihab Abdulkader9, Rafael López-López1,3,6,8, Laura Muinelo-Romay1,3,6, Clotilde Costa1,6.
Abstract
Triple-negative breast cancer (TNBC) is characterized by high rates of metastasis and no available molecular targets. CTCs derived xenografts (CDX) have demonstrated to be a promising tool for understanding cancer biology. In our study, a CDX from a TNBC patient was developed for the first time. After CDX characterization, WNT signaling was found as the main mechanism related with this tumor biology and potential CTCs markers were identified and subsequently validated in TNBC patients. In this cohort high levels of MELK expression were associated with poorer survival rates. Overall, our study demonstrates that CTCs from TNBC are tumorigenic and CDXs are a useful model to obtain valuable information about the tumor.Entities:
Keywords: CTCs-derived xenograft (CDX); MELK; circulating tumor cells (CTCs); metastasis; triple-negative breast cancer
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Year: 2018 PMID： 30450632 DOI： 10.1002/ijc.32001
Source DB: PubMed Journal: Int J Cancer ISSN： 0020-7136 Impact factor: 7.396