Takayuki Ishikawa1, Kazuhito Takeuchi2, Tetsuya Nagatani3, Yuri Aimi4, Eriko Tanemura5, Masao Tambara6, Yuichi Nagata2, Jungsu Choo7, Toshihiko Wakabayashi2. 1. Department of Neurosurgery, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan; Department of Neurosurgery, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Aichi, Japan. Electronic address: ishikawa.takayuki@h.mbox.nagoya-u.ac.jp. 2. Department of Neurosurgery, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan. 3. Department of Neurosurgery, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan; Department of Neurosurgery, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Aichi, Japan. 4. Department of Neurosurgery, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan; Department of Neurosurgery, Yokkaichi Municipal Hospital, Yokkaichi, Mie, Japan. 5. Department of Neurosurgery, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan; Department of Neurosurgery, Chuno Kosei Hospital, Seki, Gifu, Japan. 6. Department of Neurosurgery, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan; Department of Neurosurgery, Okazaki City Hospital, Okazaki, Aichi, Japan. 7. Department of Neurosurgery, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan; Department of Neurosurgery, Chukyo Hospital, Nagoya, Aichi, Japan.
Abstract
OBJECTIVE: Although reports regarding the relationship between surgical complications and quality of life (QOL) exist, a general consensus regarding this issue is lacking. The aim of this study was to evaluate QOL after endoscopic transsphenoidal approach. METHODS: We assessed patients with sellar or parasellar lesions that were removed with endoscopic transsphenoidal approach or extended endoscopic transsphenoidal approach between January 2010 and December 2016. 36-Item Short Form Health Survey and 30-Item General Health Questionnaire QOL scores were obtained preoperatively and 1 month and 6 months postoperatively. RESULTS: We analyzed 89 patients with nonfunctioning pituitary adenoma (NFPA) and 39 patients with acromegaly. Physical QOL decreased 1 month after surgery but recovered after 6 months in both groups. Mental QOL improved postoperatively compared with preoperatively. Patients with acromegaly had a worse Physical Component Summary (PCS) on 36-Item Short Form Health Survey (48.7, 28.9, and 41.0) at 6 months than patients with NFPA. The low preoperative PCS group did not improve until 6 months postoperatively. Multiple regression analysis revealed the following factors were key to postoperative QOL: age (NFPA PCS 6 months postoperatively; correlation coefficient = -0.489), preoperative Mental Component Summary (MCS) (NFPA MCS 6 months postoperatively, correlation coefficient = 0.573), body mass index (acromegaly PCS 6 months postoperatively; correlation coefficient = -0.376), preoperative PCS (acromegaly PCS 6 months postoperatively; correlation coefficient = 0.905), and preoperative MCS (acromegaly MCS 6 months postoperatively; correlation coefficient = 0.726). CONCLUSIONS: Endoscopic transsphenoidal approach can improve QOL in patients by 6 months postoperatively. In patients with acromegaly with significant QOL impairments preoperatively, surgery sometimes may be unable to normalize QOL.
OBJECTIVE: Although reports regarding the relationship between surgical complications and quality of life (QOL) exist, a general consensus regarding this issue is lacking. The aim of this study was to evaluate QOL after endoscopic transsphenoidal approach. METHODS: We assessed patients with sellar or parasellar lesions that were removed with endoscopic transsphenoidal approach or extended endoscopic transsphenoidal approach between January 2010 and December 2016. 36-Item Short Form Health Survey and 30-Item General Health Questionnaire QOL scores were obtained preoperatively and 1 month and 6 months postoperatively. RESULTS: We analyzed 89 patients with nonfunctioning pituitary adenoma (NFPA) and 39 patients with acromegaly. Physical QOL decreased 1 month after surgery but recovered after 6 months in both groups. Mental QOL improved postoperatively compared with preoperatively. Patients with acromegaly had a worse Physical Component Summary (PCS) on 36-Item Short Form Health Survey (48.7, 28.9, and 41.0) at 6 months than patients with NFPA. The low preoperative PCS group did not improve until 6 months postoperatively. Multiple regression analysis revealed the following factors were key to postoperative QOL: age (NFPA PCS 6 months postoperatively; correlation coefficient = -0.489), preoperative Mental Component Summary (MCS) (NFPA MCS 6 months postoperatively, correlation coefficient = 0.573), body mass index (acromegaly PCS 6 months postoperatively; correlation coefficient = -0.376), preoperative PCS (acromegaly PCS 6 months postoperatively; correlation coefficient = 0.905), and preoperative MCS (acromegalyMCS 6 months postoperatively; correlation coefficient = 0.726). CONCLUSIONS: Endoscopic transsphenoidal approach can improve QOL in patients by 6 months postoperatively. In patients with acromegaly with significant QOL impairments preoperatively, surgery sometimes may be unable to normalize QOL.
Authors: Ricardo Landini Lutaif Dolci; Lígia Tédde de Moraes; Ana Carolina Mayor de Carvalho; Jeniffer Cristina Kozechen Rickli; Jamile Lopes de Souza; Williams Escalante Encinas; José Viana Lima Junior; Nilza Maria Scalissi; Américo Rubens Leite Dos Santos; Paulo Roberto Lazarini Journal: Eur Arch Otorhinolaryngol Date: 2020-09-28 Impact factor: 2.503
Authors: Aleksandra Jawiarczyk-Przybyłowska; Dorota Szcześniak; Marta Ciułkowicz; Marek Bolanowski; Joanna Rymaszewska Journal: Front Endocrinol (Lausanne) Date: 2020-01-14 Impact factor: 5.555