Isabelle Soerjomataram1, Kevin Shield2, Claire Marant-Micallef3, Jerome Vignat3, Catherine Hill4, Agnes Rogel5, Gwenn Menvielle6, Laure Dossus7, Jean-Nicolas Ormsby8, Jurgen Rehm9, Lesley Rushton10, Paolo Vineis10, Max Parkin11, Freddie Bray3. 1. Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France. Electronic address: soerjomatarami@iarc.fr. 2. Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France; Centre for Addiction and Mental Health, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Canada. 3. Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France. 4. Institut Gustave Roussy, Villejuif, France. 5. Santé Publique France, Saint-Maurice, France. 6. INSERM, UMRS 1136 - (ERES), Paris, France. 7. Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France. 8. French Agency for Food, Environmental and Occupational Health & Safety, Maisons-Alfort, France. 9. Centre for Addiction and Mental Health, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Canada; Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Canada. 10. MRC-PHE Centre for Environment and Health, Imperial College London, London, UK. 11. Clinical Trials Service Unit & Epidemiological Studies Unit, University of Oxford, UK.
Abstract
BACKGROUND: Cancer is a major cause of premature illness and death in France. To quantify how cancer prevention could reduce the burden, we present estimates of the contribution of lifestyle and environmental risk factors to cancer incidence in France in 2015, comparing these with other high-income countries. METHOD: Prevalences of, and relative risks for tobacco smoking, alcohol consumption, inadequate diet, overweight and obesity, physical inactivity, exogenous hormones, suboptimal breastfeeding, infectious agents, ionising radiation, air pollution, ultraviolet exposure, occupational exposures, arsenic in drinking water and indoor benzene were obtained to estimate the population attributable fraction (PAF) and the number of attributable cancers by the cancer site and sex. RESULTS: In 2015, 41% (or 142,000 of 346,000) of all new cancers diagnosed in France could be attributed to the aforementioned risk factors. The numbers and PAF were slightly higher in men than in women (84,000 versus 58,000 cases and 44% versus 37%, respectively). Smoking (PAF: 20%), alcohol consumption (PAF: 8%), dietary factors (PAF: 5%) and excess weight (PAF: 5%) were the most important factors. Infections and occupational exposures each contributed to an additional 4% of the cancer cases in 2015. CONCLUSION: Today, two-fifths of cancers in France are attributable to preventable risk factors. The variations in the key amenable factors responsible in France relative to other economically similar countries highlight the need for tailored approaches to cancer education and prevention. Reducing smoking and alcohol consumption and the adoption of healthier diet and body weight remain important targets to reduce the increasing number of new cancer patients in France in the decades to follow.
BACKGROUND:Cancer is a major cause of premature illness and death in France. To quantify how cancer prevention could reduce the burden, we present estimates of the contribution of lifestyle and environmental risk factors to cancer incidence in France in 2015, comparing these with other high-income countries. METHOD: Prevalences of, and relative risks for tobacco smoking, alcohol consumption, inadequate diet, overweight and obesity, physical inactivity, exogenous hormones, suboptimal breastfeeding, infectious agents, ionising radiation, air pollution, ultraviolet exposure, occupational exposures, arsenic in drinking water and indoor benzene were obtained to estimate the population attributable fraction (PAF) and the number of attributable cancers by the cancer site and sex. RESULTS: In 2015, 41% (or 142,000 of 346,000) of all new cancers diagnosed in France could be attributed to the aforementioned risk factors. The numbers and PAF were slightly higher in men than in women (84,000 versus 58,000 cases and 44% versus 37%, respectively). Smoking (PAF: 20%), alcohol consumption (PAF: 8%), dietary factors (PAF: 5%) and excess weight (PAF: 5%) were the most important factors. Infections and occupational exposures each contributed to an additional 4% of the cancer cases in 2015. CONCLUSION: Today, two-fifths of cancers in France are attributable to preventable risk factors. The variations in the key amenable factors responsible in France relative to other economically similar countries highlight the need for tailored approaches to cancer education and prevention. Reducing smoking and alcohol consumption and the adoption of healthier diet and body weight remain important targets to reduce the increasing number of new cancerpatients in France in the decades to follow.
Authors: Pol Rovira; Carolin Kilian; Maria Neufeld; Harriet Rumgay; Isabelle Soerjomataram; Carina Ferreira-Borges; Kevin D Shield; Bundit Sornpaisarn; Jürgen Rehm Journal: Eur Addict Res Date: 2020-12-03 Impact factor: 3.015
Authors: G Defossez; Z Uhry; P Delafosse; E Dantony; T d'Almeida; S Plouvier; N Bossard; A M Bouvier; F Molinié; A S Woronoff; M Colonna; P Grosclaude; L Remontet; A Monnereau Journal: BMC Cancer Date: 2021-06-24 Impact factor: 4.430
Authors: Christopher P Wild; Carolina Espina; Linda Bauld; Bernardo Bonanni; Hermann Brenner; Karen Brown; Joakim Dillner; David Forman; Ellen Kampman; Mef Nilbert; Karen Steindorf; Hans Storm; Paolo Vineis; Michael Baumann; Joachim Schüz Journal: Mol Oncol Date: 2019-02-13 Impact factor: 6.603