Øystein Pettersen1,2, Elżbieta Pociask3,4, Krzysztof P Malinowski3,5, Magdalena Slezak3, Knut Hegbom6, Rune Wiseth6,7, Dag Ole Nordhaug8,7. 1. Department of Cardiothoracic Surgery, St. Olav's University Hospital, Prinsesse Kristina gate 3, 7030 Trondheim, Norway. oystepet@gmail.com. 2. Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Prinsesse Kristinas gate 3, 7030 Trondheim, Norway. oystepet@gmail.com. 3. Krakow Cardiovascular Research Institute, Krakow, Poland. 4. AGH University of Science and Technology, Department of Biocybernetics and Biomedical Engineering, Krakow, Poland. 5. Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Kraków, Poland. 6. Department of Cardiology, St. Olav's Hospital, Prinsesse Kristinas gate 3, 7030 Trondheim, Norway. 7. Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Prinsesse Kristinas gate 3, 7030 Trondheim, Norway. 8. Department of Cardiothoracic Surgery, St. Olav's University Hospital, Prinsesse Kristina gate 3, 7030 Trondheim, Norway.
Abstract
BACKGROUND: Optical coherence tomography (OCT) is a high-resolution imaging modality able to provide near-histological images of vessel walls making it possible to distinguish intima and media layers of the vessel wall separately. The use of this imaging technique is increasing while data on the variability and reliability is lacking. The aim of this study was to investigate the reproducibility of frequency-domain OCT in vein grafts used for coronary revascularization. METHODS: Five pullbacks were analyzed by the same analyst with a 1-month delay (intraobserver) and by two different analysts (interobserver). Five pairs of pullbacks from the same catheters and vein graft were also analyzed (inter pullback). RESULTS: Optical coherence tomography showed low variability in intra- and interobserver analysis with relative differences of mean media and intima thicknesses and areas of less than 5% for most parameters. Relative differences of the same parameters in the inter pullback analysis were in the 5-15% range. Intra- and interobserver reliability was excellent (intraclass correlation coefficient [ICC] > 0.90) for intima thickness and intima, media and intima-media area measurements. Inter pullback reliability was good (ICC: 0.75-0.90) for intima and intima-media area measurements, and moderate to good for mean intima thickness measurements (ICC: 0.79; 0.7338-0.8284). CONCLUSIONS: Optical coherence tomography provides good reproducibility for the measurements of parameters relevant for the development of atherosclerosis in vein grafts. CLINICAL TRIAL REGISTRATION: ID NCT01834846.
BACKGROUND: Optical coherence tomography (OCT) is a high-resolution imaging modality able to provide near-histological images of vessel walls making it possible to distinguish intima and media layers of the vessel wall separately. The use of this imaging technique is increasing while data on the variability and reliability is lacking. The aim of this study was to investigate the reproducibility of frequency-domain OCT in vein grafts used for coronary revascularization. METHODS: Five pullbacks were analyzed by the same analyst with a 1-month delay (intraobserver) and by two different analysts (interobserver). Five pairs of pullbacks from the same catheters and vein graft were also analyzed (inter pullback). RESULTS: Optical coherence tomography showed low variability in intra- and interobserver analysis with relative differences of mean media and intima thicknesses and areas of less than 5% for most parameters. Relative differences of the same parameters in the inter pullback analysis were in the 5-15% range. Intra- and interobserver reliability was excellent (intraclass correlation coefficient [ICC] > 0.90) for intima thickness and intima, media and intima-media area measurements. Inter pullback reliability was good (ICC: 0.75-0.90) for intima and intima-media area measurements, and moderate to good for mean intima thickness measurements (ICC: 0.79; 0.7338-0.8284). CONCLUSIONS: Optical coherence tomography provides good reproducibility for the measurements of parameters relevant for the development of atherosclerosis in vein grafts. CLINICAL TRIAL REGISTRATION: ID NCT01834846.
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