Literature DB >> 3043198

cis-acting translational effects of the 5' noncoding region of c-myc mRNA.

N Parkin1, A Darveau, R Nicholson, N Sonenberg.   

Abstract

We have previously shown that the 5' noncoding region of mouse c-myc mRNA has a negative effect on translational efficiency in a rabbit reticulocyte lysate (A. Darveau, J. Pelletier, and N. Sonenberg, Proc. Natl. Acad. Sci. USA 82:2315-2319, 1985). We wanted to localize and characterize the inhibitory translational element(s) in the mRNA and to study its effect in other in vitro and in vivo systems. Here we report that the restrictive element is confined to a 240-nucleotide sequence of the 5' noncoding region of mouse c-myc mRNA and that this sequence acts in cis to inhibit the translation of a heterologous mRNA. In addition, we report that the cis-inhibitory effect is also exhibited in microinjected Xenopus oocytes and wheat-germ extracts but not in HeLa cell extracts. Transfection of corresponding plasmid DNA constructs into several established cell lines did not produce the cis-inhibitory effect. A model to explain these results is presented.

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Year:  1988        PMID： 3043198      PMCID： PMC363507          DOI： 10.1128/mcb.8.7.2875-2883.1988

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  51 in total

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2.  Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system.

Authors:  P Mellon; V Parker; Y Gluzman; T Maniatis
Journal:  Cell       Date:  1981-12       Impact factor: 41.582

3.  Activation and somatic mutation of the translocated c-myc gene in burkitt lymphoma cells.

Authors:  R Taub; C Moulding; J Battey; W Murphy; T Vasicek; G M Lenoir; P Leder
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4.  Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.

Authors:  H Land; L F Parada; R A Weinberg
Journal:  Nature       Date:  1983 Aug 18-24       Impact factor: 49.962

5.  Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor.

Authors:  K Kelly; B H Cochran; C D Stiles; P Leder
Journal:  Cell       Date:  1983-12       Impact factor: 41.582

6.  Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas.

Authors:  J M Adams; S Gerondakis; E Webb; L M Corcoran; S Cory
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

7.  Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

Authors:  C M Gorman; L F Moffat; B H Howard
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8.  Transcriptionally active c-myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia.

Authors:  K B Marcu; L J Harris; L W Stanton; J Erikson; R Watt; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

Review 9.  Translocations among antibody genes in human cancer.

Authors:  P Leder; J Battey; G Lenoir; C Moulding; W Murphy; H Potter; T Stewart; R Taub
Journal:  Science       Date:  1983-11-18       Impact factor: 47.728

10.  Nucleotide sequence of cloned cDNA of human c-myc oncogene.

Authors:  R Watt; L W Stanton; K B Marcu; R C Gallo; C M Croce; G Rovera
Journal:  Nature       Date:  1983 Jun 23-29       Impact factor: 49.962
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  30 in total

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2.  Analysis of the c-myc IRES; a potential role for cell-type specific trans-acting factors and the nuclear compartment.

Authors:  M Stoneley; T Subkhankulova; J P Le Quesne; M J Coldwell; C L Jopling; G J Belsham; A E Willis
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3.  The 5' untranslated region of mRNA for ribosomal protein S19 is involved in its translational regulation during Xenopus development.

Authors:  P Mariottini; F Amaldi
Journal:  Mol Cell Biol       Date:  1990-02       Impact factor: 4.272

4.  Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells.

Authors:  S I Hsu; D Cohen; L S Kirschner; L Lothstein; M Hartstein; S B Horwitz
Journal:  Mol Cell Biol       Date:  1990-07       Impact factor: 4.272

5.  Tissue-specific promoters of the alpha human folate receptor gene yield transcripts with divergent 5' leader sequences and different translational efficiencies.

Authors:  S J Roberts; K N Chung; K Nachmanoff; P C Elwood
Journal:  Biochem J       Date:  1997-09-01       Impact factor: 3.857

6.  Effects of alterations in the leader sequence of Rous sarcoma virus RNA on initiation of translation.

Authors:  C H Hensel; R B Petersen; P B Hackett
Journal:  J Virol       Date:  1989-11       Impact factor: 5.103

7.  The 5' noncoding region of the human leukemia-associated oncogene BCR/ABL is a potent inhibitor of in vitro translation.

Authors:  A J Muller; O N Witte
Journal:  Mol Cell Biol       Date:  1989-11       Impact factor: 4.272

8.  c-Myc protein synthesis is initiated from the internal ribosome entry segment during apoptosis.

Authors:  M Stoneley; S A Chappell; C L Jopling; M Dickens; M MacFarlane; A E Willis
Journal:  Mol Cell Biol       Date:  2000-02       Impact factor: 4.272

9.  c-myc Internal ribosome entry site activity is developmentally controlled and subjected to a strong translational repression in adult transgenic mice.

Authors:  L Créancier; P Mercier; A C Prats; D Morello
Journal:  Mol Cell Biol       Date:  2001-03       Impact factor: 4.272

10.  A single nucleotide change in the c-myc internal ribosome entry segment leads to enhanced binding of a group of protein factors.

Authors:  F E Paulin; S A Chappell; A E Willis
Journal:  Nucleic Acids Res       Date:  1998-07-01       Impact factor: 16.971
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