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Literature DB >> 2601719

The 5' noncoding region of the human leukemia-associated oncogene BCR/ABL is a potent inhibitor of in vitro translation.

Abstract

The mRNA encoding the chimeric BCR/ABL oncogene, which is transcribed from the Philadelphia chromosome in human chronic myelogenous leukemia, has a 5' noncoding sequence greater than 500 bases in length which is highly GC rich and contains a short open reading frame. This untranslated sequence has a dramatic inhibitory effect upon translational efficiency in vitro. However, when BCR/ABL message is expressed in certain cell types such as the NIH 3T3 cell line, the 5' noncoding region has little inhibitory effect on translational efficiency.

Entities: Disease Gene Species

Mesh：

Year: 1989 PMID： 2601719 PMCID： PMC363679 DOI： 10.1128/mcb.9.11.5234-5238.1989

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

38 in total

1. Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency.

Authors: J Pelletier; N Sonenberg
Journal: Cell Date: 1985-03 Impact factor: 41.582

Review 2. Activation of the abl oncogene in murine and human leukemias.

Authors: J B Konopka; O N Witte
Journal: Biochim Biophys Acta Date: 1985-11-12

3. Bifunctional messenger RNAs in eukaryotes.

Authors: M Kozak
Journal: Cell Date: 1986-11-21 Impact factor: 41.582

4. Recognition of cap structure in splicing in vitro of mRNA precursors.

Authors: M M Konarska; R A Padgett; P A Sharp
Journal: Cell Date: 1984-10 Impact factor: 41.582

5. Effect of upstream reading frames on translation efficiency in simian virus 40 recombinants.

Authors: D S Peabody; S Subramani; P Berg
Journal: Mol Cell Biol Date: 1986-07 Impact factor: 4.272

6. Termination-reinitiation occurs in the translation of mammalian cell mRNAs.

Authors: D S Peabody; P Berg
Journal: Mol Cell Biol Date: 1986-07 Impact factor: 4.272

7. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.

Authors: M Kozak
Journal: Cell Date: 1986-01-31 Impact factor: 41.582

8. Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.

Authors: J B Konopka; S M Watanabe; J W Singer; S J Collins; O N Witte
Journal: Proc Natl Acad Sci U S A Date: 1985-03 Impact factor: 11.205

9. Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.

Authors: J B Konopka; O N Witte
Journal: Mol Cell Biol Date: 1985-11 Impact factor: 4.272

10. Influences of mRNA secondary structure on initiation by eukaryotic ribosomes.

Authors: M Kozak
Journal: Proc Natl Acad Sci U S A Date: 1986-05 Impact factor: 11.205

12 in total

1. Linker scanning mutagenesis of the internal ribosome entry site of poliovirus RNA.

Authors: A A Haller; B L Semler
Journal: J Virol Date: 1992-08 Impact factor: 5.103

2. Unique organization of the human BCR gene promoter.

Authors: Q S Zhu; N Heisterkamp; J Groffen
Journal: Nucleic Acids Res Date: 1990-12-11 Impact factor: 16.971

Review 3. An analysis of vertebrate mRNA sequences: intimations of translational control.

Authors: M Kozak
Journal: J Cell Biol Date: 1991-11 Impact factor: 10.539

4. Identification of the promoter region of human interleukin 1 type I receptor gene: multiple initiation sites, high G+C content, and constitutive expression.

Authors: K Ye; C A Dinarello; B D Clark
Journal: Proc Natl Acad Sci U S A Date: 1993-03-15 Impact factor: 11.205

5. The translation in vitro of rat ornithine decarboxylase mRNA is blocked by its 5' untranslated region in a polyamine-independent way.

Authors: H Van Steeg; C T Van Oostrom; H M Hodemaekers; L Peters; A A Thomas
Journal: Biochem J Date: 1991-03-01 Impact factor: 3.857