Literature DB >> 3042770

Sequence and domain structure of yeast pyruvate carboxylase.

F Lim1, C P Morris, F Occhiodoro, J C Wallace.   

Abstract

The nucleotide sequence of the yeast pyruvate carboxylase gene has been determined from a cloned fragment of yeast genomic DNA. The deduced translation product codes for a polypeptide of 1178 amino acids, having a calculated molecular weight of 130,100. The protein shows strong sequence homology to specific regions of other biotin carboxylases, lipoamide transferases, and carbamyl phosphate synthetases. The homologous regions suggest the presence of three subsites in the enzyme: a biotin attachment site, a keto acid-binding site, and an ATP-binding site. Partial proteolysis with a variety of proteases under nondenaturing conditions indicates the presence of structural domains corresponding to these subsites.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3042770

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  29 in total

1.  Cloning, sequencing, and expression of the pyruvate carboxylase gene in Lactococcus lactis subsp. lactis C2.

Authors:  H Wang; D J O'Sullivan; K A Baldwin; L L McKay
Journal:  Appl Environ Microbiol       Date:  2000-03       Impact factor: 4.792

Review 2.  Structure, function and regulation of pyruvate carboxylase.

Authors:  S Jitrapakdee; J C Wallace
Journal:  Biochem J       Date:  1999-05-15       Impact factor: 3.857

3.  Isolation and characterization of the nifUSVW-rpoN gene cluster from Rhodobacter sphaeroides.

Authors:  W G Meijer; F R Tabita
Journal:  J Bacteriol       Date:  1992-06       Impact factor: 3.490

4.  Novel insights into the biotin carboxylase domain reactions of pyruvate carboxylase from Rhizobium etli.

Authors:  Tonya N Zeczycki; Ann L Menefee; Abdussalam Adina-Zada; Sarawut Jitrapakdee; Kathy H Surinya; John C Wallace; Paul V Attwood; Martin St Maurice; W Wallace Cleland
Journal:  Biochemistry       Date:  2011-10-13       Impact factor: 3.162

5.  Acetyl-CoA carboxylase from Escherichia coli: gene organization and nucleotide sequence of the biotin carboxylase subunit.

Authors:  H Kondo; K Shiratsuchi; T Yoshimoto; T Masuda; A Kitazono; D Tsuru; M Anai; M Sekiguchi; T Tanabe
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-01       Impact factor: 11.205

6.  Differential regulation of the yeast isozymes of pyruvate carboxylase and the locus of action of acetyl CoA.

Authors:  Sarawut Jitrapakdee; Abdussalam Adina-Zada; Paul G Besant; Kathy H Surinya; W Wallace Cleland; John C Wallace; Paul V Attwood
Journal:  Int J Biochem Cell Biol       Date:  2007-03-30       Impact factor: 5.085

7.  Regulation of synthesis of pyruvate carboxylase in the photosynthetic bacterium Rhodobacter capsulatus.

Authors:  A F Yakunin; P C Hallenbeck
Journal:  J Bacteriol       Date:  1997-03       Impact factor: 3.490

8.  Genes for two subunits of acetyl coenzyme A carboxylase of Anabaena sp. strain PCC 7120: biotin carboxylase and biotin carboxyl carrier protein.

Authors:  P Gornicki; L A Scappino; R Haselkorn
Journal:  J Bacteriol       Date:  1993-08       Impact factor: 3.490

9.  Nuclear pore proteins are involved in the biogenesis of functional tRNA.

Authors:  G Simos; H Tekotte; H Grosjean; A Segref; K Sharma; D Tollervey; E C Hurt
Journal:  EMBO J       Date:  1996-05-01       Impact factor: 11.598

10.  The ACC1 gene, encoding acetyl-CoA carboxylase, is essential for growth in Ustilago maydis.

Authors:  A Bailey; J Keon; J Owen; J Hargreaves
Journal:  Mol Gen Genet       Date:  1995-11-15
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.