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Literature DB >> 30426252

Genetic variations in the ADCK1 gene predict paliperidone palmitate efficacy in Han Chinese patients with schizophrenia.

Yun-Ai Su¹, Chad Bousman², Qian Li¹, Ji-Tao Li¹, Jing-Yu Lin¹, Tian-Mei Si³.

Abstract

Genome-wide association study results have linked ADCK1 genetic variation with paliperidone efficacy in a European cohort. However, the generalizability of this locus to non-European populations is unknown. Han Chinese schizophrenia patients (n = 159) were treated with paliperidone palmitate and symptom severity was assessed over 3 months. Examination of 13 ADCK1 genetic variants revealed two single nucleotide polymorphisms (rs12590199, rs11159291) and one haplotype (rs2364747-rs12590199) associated with paliperidone palmitate response. Future work into ADCK1's function and its potential interaction with paliperidone is warranted.

Entities: Chemical Disease Gene Mutation Species

Keywords: ADCK1; Paliperidone palmitate; Pharmacogenetics; Schizophrenia

Mesh：

Substances：

Year: 2018 PMID： 30426252 DOI： 10.1007/s00702-018-1953-6

Source DB: PubMed Journal: J Neural Transm (Vienna) ISSN： 0300-9564 Impact factor: 3.575

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