| Literature DB >> 30421968 |
Tracie C Rosser1, Jamie O Edgin1, George T Capone1, Debra R Hamilton1, Emily G Allen1, Kenneth J Dooley1, Payal Anand1, John F Strang1, A Chelsea Armour1, Michelle A Frank-Crawford1, Marie Moore Channell1, Elizabeth I Pierpont1, Eleanor Feingold1, Cheryl L Maslen1, Roger H Reeves1, Stephanie L Sherman1.
Abstract
The cause of the high degree of variability in cognition and behavior among individuals with Down syndrome (DS) is unknown. We hypothesized that birth defects requiring surgery in the first years of life (congenital heart defects and gastrointestinal defects) might affect an individual's level of function. We used data from the first 234 individuals, age 6-25 years, enrolled in the Down Syndrome Cognition Project (DSCP) to test this hypothesis. Data were drawn from medical records, parent interviews, and a cognitive and behavior assessment battery. Results did not support our hypothesis. That is, we found no evidence that either birth defect was associated with poorer outcomes, adjusting for gender, race/ethnicity, and socioeconomic status. Implications for study design and measurement are discussed.Entities:
Keywords: Down syndrome; behavior; birth defect; cognition; congenital heart defect; gastrointestinal defect; intellectual disability; neuropsychological assessment; trisomy 21
Mesh：
Year: 2018 PMID： 30421968 PMCID： PMC7100339 DOI： 10.1352/1944-7558-123.6.514
Source DB: PubMed Journal: Am J Intellect Dev Disabil ISSN： 1944-7558