| Literature DB >> 28452581 |
Jamie O Edgin1, Payal Anand1, Tracie Rosser1, Elizabeth I Pierpont1, Carlos Figueroa1, Debra Hamilton1, Lillie Huddleston1, Gina Mason1, Goffredina Spanò1, Lisa Toole1, Mina Nguyen-Driver1, George Capone1, Leonard Abbeduto1, Cheryl Maslen1, Roger H Reeves1, Stephanie Sherman1.
Abstract
A multisite study investigated the test-retest reliability and practice effects of a battery of assessments to measure neurocognitive function in individuals with Down syndrome (DS). The study aimed to establish the appropriateness of these measures as potential endpoints for clinical trials. Neurocognitive tasks and parent report measures comprising the Arizona Cognitive Test Battery (ACTB) were administered to 54 young participants with DS (7-20 years of age) with mild to moderate levels of intellectual disability in an initial baseline evaluation and a follow-up assessment 3 months later. Although revisions to ACTB measures are indicated, results demonstrate adequate levels of reliability and resistance to practice effects for some measures. The ACTB offers viable options for repeated testing of memory, motor planning, behavioral regulation, and attention. Alternative measures of executive functioning are required.Entities:
Keywords: Down syndrome; cerebellum; clinical trials; cognition; hippocampus; intellectual disability; memory; neuropsychological assessment; reliability
Mesh：
Year: 2017 PMID： 28452581 PMCID： PMC6215707 DOI： 10.1352/1944-7558-122.3.215
Source DB: PubMed Journal: Am J Intellect Dev Disabil ISSN： 1944-7558