| Literature DB >> 3042049 |
T Hoang1, A Haman, O Goncalves, G G Wong, S C Clark.
Abstract
The effects of recombinant interleukin-6 (IL-6) on the proliferation of blast precursors present in the peripheral blood of patients with acute myeloblastic leukemia (AML) was investigated. IL-6 had little effect by itself; however, it synergized with granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) in the stimulation of AML blast colony formation. Responsiveness of blast progenitors to IL-6 was heterogeneous. On normal bone marrow cells the same synergy was observed on granulocyte and monocyte precursors (GM-CFC), while there was no significant effect on erythroid and multipotential precursors.Entities:
Mesh：
Substances：
Year: 1988 PMID： 3042049
Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113