| Literature DB >> 30419364 |
Yu-Wei Ge1, Jia-Wei Lu2, Zhen-Yu Sun1, Zhi-Qing Liu1, Jun Zhou2, Qin-Fei Ke2, Yuan-Qing Mao3, Ya-Ping Guo4, Zhen-An Zhu5.
Abstract
Bioglass scaffolds have great application potentials in orthopedics, and Ursolic acid (UA) can effectively promote in vivo new bone formation. Herein, we for the first time developed the mesoporous bioglass/chitosan porous scaffolds loaded with UA (MBG/CS/UA) for enhanced bone regeneration. The MBG microspheres with particle sizes of ~300 nm and pore sizes of ~3.9 nm were uniformly dispersed on the CS films. The mesoporous structure within the MBG microspheres and the hydrogen bonding between the scaffolds and UA drugs made the MBG/CS/UA scaffolds have controlled drug release performances. The as-released UA drugs from the scaffolds increased remarkably the alkaline phosphatase activity, osteogenic differentiation related gene type I collagen, runt-related transcription factor 2 expression, and osteoblast-associated protein expression. Moreover, the results of micro-CT images, histomorphological observations demonstrated that the MBG/CS/UA scaffolds improved new bone formation ability. Therefore, the MBG/CS/UA porous scaffolds can be used as novel bone tissue engineering materials.Entities:
Keywords: Bone regeneration; Drug delivery; Scaffolds; Ursolic acid
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Year: 2018 PMID： 30419364 DOI： 10.1016/j.nano.2018.10.010
Source DB: PubMed Journal: Nanomedicine ISSN： 1549-9634 Impact factor: 5.307