| Literature DB >> 30415838 |
Xing-Xing Shen1, Dana A Opulente2, Jacek Kominek2, Xiaofan Zhou3, Jacob L Steenwyk1, Kelly V Buh4, Max A B Haase5, Jennifer H Wisecaver6, Mingshuang Wang1, Drew T Doering4, James T Boudouris4, Rachel M Schneider2, Quinn K Langdon4, Moriya Ohkuma7, Rikiya Endoh7, Masako Takashima7, Ri-Ichiroh Manabe8, Neža Čadež9, Diego Libkind10, Carlos A Rosa11, Jeremy DeVirgilio12, Amanda Beth Hulfachor4, Marizeth Groenewald13, Cletus P Kurtzman12, Chris Todd Hittinger14, Antonis Rokas15.
Abstract
Budding yeasts (subphylum Saccharomycotina) are found in every biome and are as genetically diverse as plants or animals. To understand budding yeast evolution, we analyzed the genomes of 332 yeast species, including 220 newly sequenced ones, which represent nearly one-third of all known budding yeast diversity. Here, we establish a robust genus-level phylogeny comprising 12 major clades, infer the timescale of diversification from the Devonian period to the present, quantify horizontal gene transfer (HGT), and reconstruct the evolution of 45 metabolic traits and the metabolic toolkit of the budding yeast common ancestor (BYCA). We infer that BYCA was metabolically complex and chronicle the tempo and mode of genomic and phenotypic evolution across the subphylum, which is characterized by very low HGT levels and widespread losses of traits and the genes that control them. More generally, our results argue that reductive evolution is a major mode of evolutionary diversification.Entities:
Keywords: Ascomycota; Saccharomycotina; and reductive evolution; genomics; high-throughput sequencing; horizontal gene transfer; metabolic traits; molecular dating; phylogenetics; phylogenomics
Mesh：
Year: 2018 PMID： 30415838 PMCID： PMC6291210 DOI： 10.1016/j.cell.2018.10.023
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582