Literature DB >> 3041547

The carcinoembryonic antigen gene family: structure, expression and evolution.

J Thompson1, W Zimmermann.   

Abstract

The molecular cloning of carcinoembryonic antigen (CEA) and several cross-reacting antigens reveals a basic domain structure for the whole family, which shows structural similarities to the immunoglobulin superfamily. The CEA family consists of approximately 10 genes which are localized in two clusters on chromosome 19. So far, mRNA species for five of these genes have been identified which show tissue variability in their transcriptional activity. Expression of some of these genes in heterologous systems has been achieved, allowing the localization of some epitopes. The characterization of a CEA gene family in the rat and a comparison with its human counterpart has been utilized in the development of an evolutionary model.

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Year:  1988        PMID： 3041547     DOI： 10.1159/000217547

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  21 in total

Review 1.  The role of CD15-(Le(X))-related carbohydrates in neutrophil adhesion.

Authors:  M A Kerr; S C Stocks
Journal:  Histochem J       Date:  1992-11

Review 2.  Molecular events regulating messenger RNA stability in eukaryotes.

Authors:  K S Saini; I C Summerhayes; P Thomas
Journal:  Mol Cell Biochem       Date:  1990-07-17       Impact factor: 3.396

3.  Binding of nonspecific cross-reacting antigen, a granulocyte membrane glycoprotein, to Escherichia coli expressing type 1 fimbriae.

Authors:  S L Sauter; S M Rutherfurd; C Wagener; J E Shively; S A Hefta
Journal:  Infect Immun       Date:  1991-07       Impact factor: 3.441

4.  Evolutionary analysis of the multigene pregnancy-specific beta 1-glycoprotein family: separation of historical and nonhistorical signals.

Authors:  P A McLenachan; P J Lockhart; H R Faber; B C Mansfield
Journal:  J Mol Evol       Date:  1996-02       Impact factor: 2.395

Review 5.  Cell adhesion molecules of the immunoglobulin supergene family and their role in malignant transformation and progression to metastatic disease.

Authors:  J P Johnson
Journal:  Cancer Metastasis Rev       Date:  1991-05       Impact factor: 9.264

6.  Intra- and interspecies analyses of the carcinoembryonic antigen (CEA) gene family reveal independent evolution in primates and rodents.

Authors:  F Rudert; W Zimmermann; J A Thompson
Journal:  J Mol Evol       Date:  1989-08       Impact factor: 2.395

7.  Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression.

Authors:  H Schrewe; J Thompson; M Bona; L J Hefta; A Maruya; M Hassauer; J E Shively; S von Kleist; W Zimmermann
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272

8.  Immune response to the carcinoembryonic antigen in patients treated with an anti-idiotype antibody vaccine.

Authors:  K A Foon; M Chakraborty; W J John; A Sherratt; H Köhler; M Bhattacharya-Chatterjee
Journal:  J Clin Invest       Date:  1995-07       Impact factor: 14.808

Review 9.  Clinicopathological utility of sialoglycoconjugates in diagnosing and treating colorectal cancer.

Authors:  Yoshinori Inagaki; Jianjun Gao; Peipei Song; Norihiro Kokudo; Munehiro Nakata; Wei Tang
Journal:  World J Gastroenterol       Date:  2014-05-28       Impact factor: 5.742

Review 10.  Carcinoembryonic antigen: function in metastasis by human colorectal carcinoma.

Authors:  J M Jessup; P Thomas
Journal:  Cancer Metastasis Rev       Date:  1989-12       Impact factor: 9.264
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