| Literature DB >> 30414157 |
Raymond Liang1,2, Vijay Menon1, Saghi Ghaffari3,4,5,6.
Abstract
Two and half million red blood cells (RBC) are generated every second in a healthy adult. The process of RBC production known as erythropoiesis requires a meticulous synchrony between signaling processes and the activity of many transcription factor complexes. FOXO3 is a transcription factor that is responsive to signaling processes and essential for the erythroid proliferation and maturation, RBC formation, and lifespan. Here, we discuss how using an integrated computational and experimental systems biology approach new and unanticipated FOXO3 functions in terminal erythropoiesis were uncovered. These combinatory approaches identified FOXO3 as a key regulator of terminal erythropoiesis. As a result, a new mode of FOXO3 participation in erythroid transcription complex formation has been proposed.Entities:
Keywords: Enucleation; Erythropoiesis; FOXO; FOXO3; Mitochondria; Mitophagy; RNA sequencing; Red blood cell (RBC); Transcriptome
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Year: 2019 PMID： 30414157 PMCID： PMC6900592 DOI： 10.1007/978-1-4939-8900-3_18
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745