Akinkunmi Paul Okekunle1,2, Meng Zhang2, Zhen Wang3, Justina Ucheojor Onwuka4, Xiaoyan Wu2, Rennan Feng5, Chunlong Li6. 1. Department of General Surgery, Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, 150081, People's Republic of China. 2. Department of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, Heilongjiang, 150081, People's Republic of China. 3. Mudanjiang City Health Supervision, Mudanjiang, Heilongjiang, People's Republic of China. 4. Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, Heilongjiang, 150081, People's Republic of China. 5. Department of Nutrition and Food Hygiene, College of Public Health, Harbin Medical University, Harbin, Heilongjiang, 150081, People's Republic of China. fengrennan@163.com. 6. Department of General Surgery, Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, 150081, People's Republic of China. lichunlong1981@163.com.
Abstract
AIM: To assess whether oral branched-chain amino acids (BCAA) supplementation exerts influence on circulating BCAA and the significance of dietary BCAA in type 2 diabetes and obesity risk. METHOD: We searched PUBMED, EMBASE and Cochrane library through June 2018 to retrieve and screen published reports for inclusion in the meta-analysis after methodological assessment. Heterogeneity of studies was evaluated using I2 statistics, while sensitivity analysis and funnel plot were used to evaluate the potential effect of individual studies on the overall estimates and publication bias, respectively, using RevMan 5.3. RESULT: Eight articles on randomized clinical trial of oral BCAA supplementation, and seven articles on dietary BCAA intake and type 2 diabetes/obesity risks were eligible for inclusion in our meta-analyses. Mean difference and 95% confidence interval (CI) of circulating leucine was 39.65 (3.54, 75.76) µmol/L, P = 0.03 post-BCAA supplementation. Also, OR and 95% CI for higher total BCAA intake and metabolic disorder risks were, 1.32 (1.14, 1.53), P = 0.0003-type 2 diabetes and 0.62 (0.47, 0.82), P = 0.0008-obesity. CONCLUSION: Oral BCAA supplementation exerts modest influence on circulating leucine profile and higher total BCAA intake is positively and contra-positively associated with type 2 diabetes and obesity risk, respectively.
AIM: To assess whether oral branched-chain amino acids (BCAA) supplementation exerts influence on circulating BCAA and the significance of dietary BCAA in type 2 diabetes and obesity risk. METHOD: We searched PUBMED, EMBASE and Cochrane library through June 2018 to retrieve and screen published reports for inclusion in the meta-analysis after methodological assessment. Heterogeneity of studies was evaluated using I2 statistics, while sensitivity analysis and funnel plot were used to evaluate the potential effect of individual studies on the overall estimates and publication bias, respectively, using RevMan 5.3. RESULT: Eight articles on randomized clinical trial of oral BCAA supplementation, and seven articles on dietary BCAA intake and type 2 diabetes/obesity risks were eligible for inclusion in our meta-analyses. Mean difference and 95% confidence interval (CI) of circulating leucine was 39.65 (3.54, 75.76) µmol/L, P = 0.03 post-BCAA supplementation. Also, OR and 95% CI for higher total BCAA intake and metabolic disorder risks were, 1.32 (1.14, 1.53), P = 0.0003-type 2 diabetes and 0.62 (0.47, 0.82), P = 0.0008-obesity. CONCLUSION: Oral BCAA supplementation exerts modest influence on circulating leucine profile and higher total BCAA intake is positively and contra-positively associated with type 2 diabetes and obesity risk, respectively.
Entities:
Keywords:
Branched-chain amino acids; Meta-analysis; Obesity; Type 2 diabetes
Authors: Rikuta Hamaya; Samia Mora; Patrick R Lawler; Nancy R Cook; Julie E Buring; I-Min Lee; JoAnn E Manson; Deirdre K Tobias Journal: J Nutr Date: 2022-06-09 Impact factor: 4.687
Authors: Akinkunmi Paul Okekunle; Heejin Lee; Sherlyn Mae P Provido; Grace H Chung; Sangmo Hong; Sung Hoon Yu; Chang Beom Lee; Jung Eun Lee Journal: BMC Public Health Date: 2022-04-05 Impact factor: 3.295