Literature DB >> 30413867

Repair of colonic neovaginal stenosis using a biological graft in a male-to-female transgender patient.

Ankita Gupta1, Sean Francis2, Ryan Stewart2, Deslyn Hobson2, Kate V Meriwether2.   

Abstract

INTRODUCTION AND HYPOTHESIS: One in 2900 genotypical men report gender dysphoria, and many undergo gender confirmation surgery to match their physical phenotype to their identity. A variety of surgical techniques are used in male-to-female transgender patients, one of which is bowel vaginoplasty, and postoperative stenosis of the colonic neovagina is common. Extracellular matrix grafts have been used in vaginal reconstruction. with porcine urinary bladder matrix (UBM) acting as a scaffold for smooth-muscle tissue and matrix regeneration. The aim of this surgical video is to describe the use of a UBM biological graft in repair of introital stenosis due to recurrent granulation tissue in the colonic neovagina of a male-to-female transgender patient.
METHODS: A 32-year-old male-to-female transgender patient with a history of rectosigmoid neovagina formation for genital gender confirmation surgery 12 months prior presented with genital granulation tissue and stenosis of her neovaginal introitus. Despite two surgical revisions, the patient developed recurrence of granulation tissue and obliteration of the neovaginal introitus, preventing sexual function of the neovagina.
RESULTS: Reconstruction of the neovaginal introitus was performed using UBM. The patient noted improvement in comfort, hygiene, and quality of life following the procedure. This video describes our surgical technique and perioperative clinical findings.
CONCLUSIONS: We report the novel use of UBM biological graft in the revision of a neovaginal introitus after former rectosigmoid vaginoplasty in a male-to-female transgender patient.

Entities:  

Keywords:  Biological graft; Extracellular matrix; Matristem; Neovagina; Stenosis; Transgender

Mesh:

Year:  2018        PMID: 30413867     DOI: 10.1007/s00192-018-3800-6

Source DB:  PubMed          Journal:  Int Urogynecol J        ISSN: 0937-3462            Impact factor:   2.894


  7 in total

1.  Urinary bladder matrix promotes site appropriate tissue formation following right ventricle outflow tract repair.

Authors:  Nathaniel T Remlinger; Thomas W Gilbert; Masahiro Yoshida; Brogan N Guest; Ryotaro Hashizume; Michelle L Weaver; William R Wagner; Bryan N Brown; Kimimasa Tobita; Peter D Wearden
Journal:  Organogenesis       Date:  2013-06-25       Impact factor: 2.500

2.  Short-term results of treating primary and recurrent anal fistulas with a novel extracellular matrix derived from porcine urinary bladder.

Authors:  Tara Iorio; David Blumberg
Journal:  Am Surg       Date:  2015-05       Impact factor: 0.688

3.  Repair of a recurrent rectovaginal fistula with a biological graft.

Authors:  Kate Berger; Jonathan Faro; Sebastian Faro
Journal:  Int Urogynecol J       Date:  2015-05-05       Impact factor: 2.894

Review 4.  Outcome of Vaginoplasty in Male-to-Female Transgenders: A Systematic Review of Surgical Techniques.

Authors:  Sophie E R Horbach; Mark-Bram Bouman; Jan Maerten Smit; Müjde Özer; Marlon E Buncamper; Margriet G Mullender
Journal:  J Sex Med       Date:  2015-03-26       Impact factor: 3.802

Review 5.  Transgender people: health at the margins of society.

Authors:  Sam Winter; Milton Diamond; Jamison Green; Dan Karasic; Terry Reed; Stephen Whittle; Kevan Wylie
Journal:  Lancet       Date:  2016-06-17       Impact factor: 79.321

6.  Towards rebuilding vaginal support utilizing an extracellular matrix bioscaffold.

Authors:  Rui Liang; Katrina Knight; Deanna Easley; Stacy Palcsey; Steven Abramowitch; Pamela A Moalli
Journal:  Acta Biomater       Date:  2017-05-06       Impact factor: 8.947

Review 7.  Complications of the neovagina in male-to-female transgender surgery: A systematic review and meta-analysis with discussion of management.

Authors:  Paulette Cutruzzula Dreher; Daniel Edwards; Shaun Hager; Margeaux Dennis; Andie Belkoff; Jamie Mora; Susan Tarry; Kathy L Rumer
Journal:  Clin Anat       Date:  2017-11-10       Impact factor: 2.414

  7 in total

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