Literature DB >> 30402762

α-Fetoprotein Influence on the Conversion of Naïve T-Helpers into Memory T-Cell Effector Subpopulations.

S A Zamorina1,2, V P Timganova3, M S Bochkova1, P V Khramtsov1,2, K A Fomicheva2, M B Rayev1,2,4, V A Chereshnev1,2,4.   

Abstract

The effect of native α-fetoprotein (AFP) on the conversion of naïve T-helpers into central memory T-cells (TCM) and effector subpopulations of the preterminally differentiated (TEM) and terminally differentiated (TEMRA) memory T-cells was studied. AFP was found to prevent the conversion of naïve T-helpers into effector subpopulations of memory T cells (TEM and TEMRA) while reducing the total production of IL-4 and IFN-γ by the studied cell populations. The data reveal a new role of AFP in the immune tolerance formation during pregnancy.

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Year:  2018        PMID： 30402762     DOI： 10.1134/S0012496618050113

Source DB:  PubMed          Journal:  Dokl Biol Sci        ISSN： 0012-4966


  10 in total

Review 1.  Properties of end-stage human T cells defined by CD45RA re-expression.

Authors:  Sian M Henson; Natalie E Riddell; Arne N Akbar
Journal:  Curr Opin Immunol       Date:  2012-05-01       Impact factor: 7.486

Review 2.  The alpha-fetoprotein third domain receptor binding fragment: in search of scavenger and associated receptor targets.

Authors:  G J Mizejewski
Journal:  J Drug Target       Date:  2015-03-13       Impact factor: 5.121

Review 3.  Human memory T cells: generation, compartmentalization and homeostasis.

Authors:  Donna L Farber; Naomi A Yudanin; Nicholas P Restifo
Journal:  Nat Rev Immunol       Date:  2013-12-13       Impact factor: 53.106

4.  Role of α-fetoprotein in differentiation of regulatory T lymphocytes.

Authors:  V A Chereshnev; V P Timganova; S A Zamorina; M S Bochkova; P V Khramtsov; M D Kropaneva; M B Raev
Journal:  Dokl Biol Sci       Date:  2018-01-04

5.  Innate immune cell CD45 regulates lymphopenia-induced T cell proliferation.

Authors:  Amy E Saunders; Yaein A Shim; Pauline Johnson
Journal:  J Immunol       Date:  2014-08-11       Impact factor: 5.422

6.  Pregnancy persistently affects memory T cell populations.

Authors:  Tom E C Kieffer; Marijke M Faas; Sicco A Scherjon; Jelmer R Prins
Journal:  J Reprod Immunol       Date:  2016-11-11       Impact factor: 4.054

Review 7.  Alpha-fetoprotein: a renaissance.

Authors:  A A Terentiev; N T Moldogazieva
Journal:  Tumour Biol       Date:  2013-06-14

Review 8.  Central memory and effector memory T cell subsets: function, generation, and maintenance.

Authors:  Federica Sallusto; Jens Geginat; Antonio Lanzavecchia
Journal:  Annu Rev Immunol       Date:  2004       Impact factor: 28.527

9.  Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells.

Authors:  J Geginat; F Sallusto; A Lanzavecchia
Journal:  J Exp Med       Date:  2001-12-17       Impact factor: 14.307

Review 10.  Endocrine factors modulating immune responses in pregnancy.

Authors:  Anne Schumacher; Serban-Dan Costa; Ana Claudia Zenclussen
Journal:  Front Immunol       Date:  2014-05-08       Impact factor: 7.561
  10 in total

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