Literature DB >> 29299806

Role of α-fetoprotein in differentiation of regulatory T lymphocytes.

V A Chereshnev1,2,3, V P Timganova4, S A Zamorina1,2, M S Bochkova1, P V Khramtsov1,2, M D Kropaneva2, M B Raev1,2,3.   

Abstract

The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4+ lymphocytes with different proliferative status was studied. α-Fetoprotein did not affect the ratio of proliferating and non-proliferating activated CD4+ cells. In the study of Treg differentiation, it was found that AFP at concentrations of 50 and 100 μg/mL significantly inhibited the number of nonproliferating CD4+FOXP3+ and CD4+FOXP3+HELIOS+ lymphocytes without affecting the expression of Treg markers by proliferating CD4+ lymphocytes.

Entities:  

Mesh：

Substances：

Year:  2018        PMID： 29299806     DOI： 10.1134/S0012496617060084

Source DB:  PubMed          Journal:  Dokl Biol Sci        ISSN： 0012-4966


  9 in total

1.  The evaluation of survival and proliferation of lymphocytes in autologous mixed leukocyte reaction with dendritic cells. The comparison of incorporation of (3)H-thymidine and differential gating method.

Authors:  Romana Veselá; Ludmila Doležalová; Robert Pytlík; Hana Rychtrmocová; Helena Marečková; Marek Trněný
Journal:  Cell Immunol       Date:  2011-07-06       Impact factor: 4.868

Review 2.  The alpha-fetoprotein third domain receptor binding fragment: in search of scavenger and associated receptor targets.

Authors:  G J Mizejewski
Journal:  J Drug Target       Date:  2015-03-13       Impact factor: 5.121

3.  Light scatter analysis and sorting of cells activated in mixed leukocyte culture.

Authors:  H R MacDonald; P Zaech
Journal:  Cytometry       Date:  1982-07

4.  Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells.

Authors:  Angela M Thornton; Patricia E Korty; Dat Q Tran; Elizabeth A Wohlfert; Patrick E Murray; Yasmine Belkaid; Ethan M Shevach
Journal:  J Immunol       Date:  2010-02-24       Impact factor: 5.422

Review 5.  Regulatory T cell memory.

Authors:  Michael D Rosenblum; Sing Sing Way; Abul K Abbas
Journal:  Nat Rev Immunol       Date:  2015-12-21       Impact factor: 53.106

Review 6.  The T helper type 17/regulatory T cell paradigm in pregnancy.

Authors:  Ana Sofia Figueiredo; Anne Schumacher
Journal:  Immunology       Date:  2016-05       Impact factor: 7.397

Review 7.  Alpha-fetoprotein: a renaissance.

Authors:  A A Terentiev; N T Moldogazieva
Journal:  Tumour Biol       Date:  2013-06-14

Review 8.  Endocrine factors modulating immune responses in pregnancy.

Authors:  Anne Schumacher; Serban-Dan Costa; Ana Claudia Zenclussen
Journal:  Front Immunol       Date:  2014-05-08       Impact factor: 7.561

9.  Helios, and not FoxP3, is the marker of activated Tregs expressing GARP/LAP.

Authors:  Eyad Elkord; May Abd Al Samid; Belal Chaudhary
Journal:  Oncotarget       Date:  2015-08-21
  9 in total
  2 in total

1.  α-Fetoprotein Influence on the Conversion of Naïve T-Helpers into Memory T-Cell Effector Subpopulations.

Authors:  S A Zamorina; V P Timganova; M S Bochkova; P V Khramtsov; K A Fomicheva; M B Rayev; V A Chereshnev
Journal:  Dokl Biol Sci       Date:  2018-11-06

2.  Elevated alpha-fetoprotein in asymptomatic adults: Clinical features, outcome, and association with body composition.

Authors:  Sangmi Jang; Gwang Hyeon Choi; Won Chang; Eun Sun Jang; Jin-Wook Kim; Sook-Hyang Jeong
Journal:  PLoS One       Date:  2022-07-21       Impact factor: 3.752
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.