Tal Marom1, Oded Kraus1, Nadeem Habashi1, Sharon Ovnat Tamir1. 1. 1 Department of Otolaryngology-Head and Neck Surgery, Samson Assuta Ashdod University Hospital, Ben Gurion University Faculty of Health Sciences, Ashdod, Israel.
Abstract
OBJECTIVE: To review new experimental techniques for the diagnosis of otitis media (OM). DATA SOURCES: Literature search in English in the following databases: MEDLINE (via PubMed), Ovid Medline, Google Scholar, and Clinical Evidence (BMJ Publishing) between January 1, 2005, and April 30, 2018. Subsequently, articles were reviewed and included only if relevant. REVIEW METHODS: MeSH terms: ["diagnosis"] AND [all forms of OM] AND ["human"] AND ["ear"] and ["tympanic membrane"]. The retrieved innovative diagnostic techniques rely on and take advantage of the physical properties of the tympanomastoid cavity components: tympanic membrane (TM) thickness, its translucency and compliance; middle ear fluid characteristics; biofilm presence; increased tissue metabolic activity in OM states; and fluid presence in the mastoid cavity. These parameters are taken into account to establish OM diagnosis objectively. We review spectral gradient acoustic reflectometry, digital otoscopy, TM image analysis, multicolor reflectance imaging, anticonfocal middle ear assessment, optical coherence tomography, quantitative pneumatic otoscopy, transmastoid ultrasound, wideband measurements, TM thickness mapping, shortwave infrared imaging, and wideband acoustic transfer functions. CONCLUSIONS: New experimental techniques are gradually introduced to overcome the limitations of standard otoscopy. The aforementioned techniques are still under investigation and are pending widespread clinical use. The implementation of these techniques in the market is dependent on their success in clinical trials, as well as on their future cost. IMPLICATION FOR PRACTICE: New techniques for the diagnosis of OM can objectively evaluate the morphology of the TM, determine the presence of middle ear fluid and evaluate its content, and thus potentially replace standard otoscopy.
OBJECTIVE: To review new experimental techniques for the diagnosis of otitis media (OM). DATA SOURCES: Literature search in English in the following databases: MEDLINE (via PubMed), Ovid Medline, Google Scholar, and Clinical Evidence (BMJ Publishing) between January 1, 2005, and April 30, 2018. Subsequently, articles were reviewed and included only if relevant. REVIEW METHODS: MeSH terms: ["diagnosis"] AND [all forms of OM] AND ["human"] AND ["ear"] and ["tympanic membrane"]. The retrieved innovative diagnostic techniques rely on and take advantage of the physical properties of the tympanomastoid cavity components: tympanic membrane (TM) thickness, its translucency and compliance; middle ear fluid characteristics; biofilm presence; increased tissue metabolic activity in OM states; and fluid presence in the mastoid cavity. These parameters are taken into account to establish OM diagnosis objectively. We review spectral gradient acoustic reflectometry, digital otoscopy, TM image analysis, multicolor reflectance imaging, anticonfocal middle ear assessment, optical coherence tomography, quantitative pneumatic otoscopy, transmastoid ultrasound, wideband measurements, TM thickness mapping, shortwave infrared imaging, and wideband acoustic transfer functions. CONCLUSIONS: New experimental techniques are gradually introduced to overcome the limitations of standard otoscopy. The aforementioned techniques are still under investigation and are pending widespread clinical use. The implementation of these techniques in the market is dependent on their success in clinical trials, as well as on their future cost. IMPLICATION FOR PRACTICE: New techniques for the diagnosis of OM can objectively evaluate the morphology of the TM, determine the presence of middle ear fluid and evaluate its content, and thus potentially replace standard otoscopy.
Authors: Jungeun Won; Ryan G Porter; Michael A Novak; Jon Youakim; Ada Sum; Ronit Barkalifa; Edita Aksamitiene; Anqi Zhang; Ryan Nolan; Ryan Shelton; Stephen A Boppart Journal: J Biophotonics Date: 2020-08-18 Impact factor: 3.207
Authors: Jungeun Won; Wenzhou Hong; Pawjai Khampang; Darold R Spillman; Samuels Marshall; Ke Yan; Ryan G Porter; Michael A Novak; Joseph E Kerschner; Stephen A Boppart Journal: Sci Rep Date: 2021-03-04 Impact factor: 4.379
Authors: Jungeun Won; Guillermo L Monroy; Roshan I Dsouza; Darold R Spillman; Jonathan McJunkin; Ryan G Porter; Jindou Shi; Edita Aksamitiene; MaryEllen Sherwood; Lindsay Stiger; Stephen A Boppart Journal: Biosensors (Basel) Date: 2021-05-03
Authors: Rustin G Kashani; Marcel C Młyńczak; David Zarabanda; Paola Solis-Pazmino; David M Huland; Iram N Ahmad; Surya P Singh; Tulio A Valdez Journal: Sci Rep Date: 2021-06-15 Impact factor: 4.379