| Literature DB >> 30393163 |
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used agents for the treatment of acute and chronic pain. However, it has long been recognized that there is substantial inter-individual variability in the analgesic response to NSAIDs, reflecting the complex interplay between mechanisms of pain, differences between distinct NSAIDs, and patient-specific factors such as genetic variation. This review summarizes the current knowledge regarding how these factors contribute to variability in the analgesic response to NSAIDs.Entities:
Keywords: Analgesia; Cyclooxygenase; Non-steroidal anti-inflammatory drugs; Pain; Prostanoids; Variability
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Year: 2018 PMID: 30393163 DOI: 10.1016/j.prostaglandins.2018.10.005
Source DB: PubMed Journal: Prostaglandins Other Lipid Mediat ISSN: 1098-8823 Impact factor: 3.072