AIMS: Microvolt T-wave alternans (MTWA) testing is a beat-to-beat fluctuation in the amplitude of T wave. We investigated whether: (a) MTWA can be new non-invasive tool for detection of reversible ischemia in patients with suspected CAD without structural heart disease, (b) MTWA can detect ischemia earlier and with greater test accuracy compared with exercise ECG ST-segment testing, and (c) threshold value of MTWA and heart rate at which the alternans is estimated can be different compared to standard values. METHODS: A total of 101 patients with suspected stable coronary disease, but without structural heart disease, were included. Echocardiography, exercise ECG test, MTWA with classical and modified threshold alternans values, and coronary angiography were performed. RESULTS: About 33.3% patients had a false-positive result on exercise ECG test. The sensitivity of exercise ECG ST-segment test in the detection of coronary artery disease was 97.8%, and the specificity was 42.5% (DOR 33.89). In a group of angiographically positive patients, standard MTWA accurately identified 60% of patients, while 40% had a false-negative result. About 91.8% patients with negative angiography result were accurately identified with 8.2% false positives. The sensitivity of MTWA was 59.61% and specificity 91.83%. Best ratio of sensitivity and specificity (86.53% and 95.91%, DOR 151.06) had modified criteria for positive MTWA (MTWA >1.5 µV at heart rate 115-125/min). CONCLUSIONS: This study showed that MTWA can be the new non-invasive tool for the detection of reversible ischemia in patients with suspected CAD without structural heart disease. Also, MTWA can detect ischemia earlier and with greater accuracy compared with exercise ECG testing.
AIMS: Microvolt T-wave alternans (MTWA) testing is a beat-to-beat fluctuation in the amplitude of T wave. We investigated whether: (a) MTWA can be new non-invasive tool for detection of reversible ischemia in patients with suspected CAD without structural heart disease, (b) MTWA can detect ischemia earlier and with greater test accuracy compared with exercise ECG ST-segment testing, and (c) threshold value of MTWA and heart rate at which the alternans is estimated can be different compared to standard values. METHODS: A total of 101 patients with suspected stable coronary disease, but without structural heart disease, were included. Echocardiography, exercise ECG test, MTWA with classical and modified threshold alternans values, and coronary angiography were performed. RESULTS: About 33.3% patients had a false-positive result on exercise ECG test. The sensitivity of exercise ECG ST-segment test in the detection of coronary artery disease was 97.8%, and the specificity was 42.5% (DOR 33.89). In a group of angiographically positive patients, standard MTWA accurately identified 60% of patients, while 40% had a false-negative result. About 91.8% patients with negative angiography result were accurately identified with 8.2% false positives. The sensitivity of MTWA was 59.61% and specificity 91.83%. Best ratio of sensitivity and specificity (86.53% and 95.91%, DOR 151.06) had modified criteria for positive MTWA (MTWA >1.5 µV at heart rate 115-125/min). CONCLUSIONS: This study showed that MTWA can be the new non-invasive tool for the detection of reversible ischemia in patients with suspected CAD without structural heart disease. Also, MTWA can detect ischemia earlier and with greater accuracy compared with exercise ECG testing.
Authors: Tessa S S Genders; Ewout W Steyerberg; Hatem Alkadhi; Sebastian Leschka; Lotus Desbiolles; Koen Nieman; Tjebbe W Galema; W Bob Meijboom; Nico R Mollet; Pim J de Feyter; Filippo Cademartiri; Erica Maffei; Marc Dewey; Elke Zimmermann; Michael Laule; Francesca Pugliese; Rossella Barbagallo; Valentin Sinitsyn; Jan Bogaert; Kaatje Goetschalckx; U Joseph Schoepf; Garrett W Rowe; Joanne D Schuijf; Jeroen J Bax; Fleur R de Graaf; Juhani Knuuti; Sami Kajander; Carlos A G van Mieghem; Matthijs F L Meijs; Maarten J Cramer; Deepa Gopalan; Gudrun Feuchtner; Guy Friedrich; Gabriel P Krestin; M G Myriam Hunink Journal: Eur Heart J Date: 2011-03-02 Impact factor: 29.983
Authors: Stephen E P Smith; Jennifer Li; Krassimira Garbett; Karoly Mirnics; Paul H Patterson Journal: J Neurosci Date: 2007-10-03 Impact factor: 6.167
Authors: Harvey S Singer; Christina Morris; Colin Gause; Matthew Pollard; Andrew W Zimmerman; Mikhail Pletnikov Journal: J Neuroimmunol Date: 2009-04-10 Impact factor: 3.478
Authors: Amar Sarkar; Soili M Lehto; Siobhán Harty; Timothy G Dinan; John F Cryan; Philip W J Burnet Journal: Trends Neurosci Date: 2016-10-25 Impact factor: 13.837