Literature DB >> 30382442

ASD Comorbidity in Fragile X Syndrome: Symptom Profile and Predictors of Symptom Severity in Adolescent and Young Adult Males.

Leonard Abbeduto1,2, Angela John Thurman3, Andrea McDuffie3, Jessica Klusek4, Robyn Tempero Feigles3, W Ted Brown5, Danielle J Harvey3, Tatyana Adayev5, Giuseppe LaFauci5, Carl Dobkins5, Jane E Roberts4.   

Abstract

Many males with FXS meet criteria for ASD. This study was designed to (1) describe ASD symptoms in adolescent and young adult males with FXS (n = 44) and (2) evaluate the contributions to ASD severity of cognitive, language, and psychiatric factors, as well as FMRP (the protein deficient in FXS). A few ASD symptoms on the ADOS-2 were universal in the sample. There was less impairment in restricted and repetitive behaviors (RRB) than in the social affective (SA) domain. The best predictor of overall ASD severity and SA severity was expressive syntactic ability. RRB severity was best predicted by the psychiatric factors. Implications for clinical practice and for understanding the ASD comorbidity in FXS are discussed.

Entities:  

Keywords:  Autism spectrum disorder; FMRP; Fragile X syndrome; IQ; Language; Psychiatric symptoms

Mesh：

Year:  2019        PMID： 30382442      PMCID： PMC6556533          DOI： 10.1007/s10803-018-3796-2

Source DB:  PubMed          Journal:  J Autism Dev Disord        ISSN： 0162-3257


  92 in total

1.  A componential view of theory of mind: evidence from Williams syndrome.

Authors:  H Tager-Flusberg; K Sullivan
Journal:  Cognition       Date:  2000-07-14

2.  Conversational characteristics of children with fragile X syndrome: repetitive speech.

Authors:  R C Belser; V Sudhalter
Journal:  Am J Ment Retard       Date:  2001-01

3.  FMRP expression as a potential prognostic indicator in fragile X syndrome.

Authors:  F Tassone; R J Hagerman; D N Iklé; P N Dyer; M Lampe; R Willemsen; B A Oostra; A K Taylor
Journal:  Am J Med Genet       Date:  1999-05-28

4.  Autistic behavior, FMR1 protein, and developmental trajectories in young males with fragile X syndrome.

Authors:  D B Bailey; D D Hatton; M Skinner; G Mesibov
Journal:  J Autism Dev Disord       Date:  2001-04

5.  Early development, temperament, and functional impairment in autism and fragile X syndrome.

Authors:  D B Bailey; D D Hatton; G Mesibov; N Ament; M Skinner
Journal:  J Autism Dev Disord       Date:  2000-02

6.  Conversational characteristics of children with fragile X syndrome: tangential language.

Authors:  V Sudhalter; R C Belser
Journal:  Am J Ment Retard       Date:  2001-09

7.  The behavioral phenotype in fragile X: symptoms of autism in very young children with fragile X syndrome, idiopathic autism, and other developmental disorders.

Authors:  S J Rogers; D E Wehner; R Hagerman
Journal:  J Dev Behav Pediatr       Date:  2001-12       Impact factor: 2.225

8.  Self-injurious behavior in young boys with fragile X syndrome.

Authors:  Frank J Symons; Renee D Clark; Deborah D Hatton; Martie Skinner; Donald B Bailey
Journal:  Am J Med Genet A       Date:  2003-04-15       Impact factor: 2.802

9.  Behavioral relationship between autism and fragile x syndrome.

Authors:  Jenny L Demark; Maurice A Feldman; Jeanette J A Holden
Journal:  Am J Ment Retard       Date:  2003-09

Review 10.  FMR1 and the fragile X syndrome: human genome epidemiology review.

Authors:  D C Crawford; J M Acuña; S L Sherman
Journal:  Genet Med       Date:  2001 Sep-Oct       Impact factor: 8.822
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  28 in total

1.  Emergence and rate of autism in fragile X syndrome across the first years of life.

Authors:  Jane E Roberts; Jessica Bradshaw; Elizabeth Will; Abigail L Hogan; Samuel McQuillin; Kimberly Hills
Journal:  Dev Psychopathol       Date:  2020-10

2.  "Are We Done Yet?" Question-Asking in Boys With Fragile X Syndrome and Idiopathic Autism Spectrum Disorder.

Authors:  Laura Friedman; Emily Lorang; Elizabeth Hilvert; Audra Sterling
Journal:  J Speech Lang Hear Res       Date:  2020-05-18       Impact factor: 2.297

3.  Rethinking Measurement Standards of Autism Symptomology in Adolescents with Fragile X Syndrome.

Authors:  Heather Fielding-Gebhardt; Shelley L Bredin-Oja; Steven F Warren; Nancy C Brady
Journal:  J Autism Dev Disord       Date:  2021-02-06

4.  A novel eye-tracking paradigm for indexing social avoidance-related behavior in fragile X syndrome.

Authors:  Jessica Klusek; Carly Moser; Joseph Schmidt; Leonard Abbeduto; Jane E Roberts
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2019-08-16       Impact factor: 3.568

5.  Daily Living Skills in Adolescent and Young Adult Males With Fragile X Syndrome.

Authors:  Angela John Thurman; Stephanie Summers Swinehart; Jessica Klusek; Jane E Roberts; Lauren Bullard; Jocelyn Christina B Marzan; W Ted Brown; Leonard Abbeduto
Journal:  Am J Intellect Dev Disabil       Date:  2022-01-01

6.  The FMR1 Premutation Phenotype and Mother-Youth Synchrony in Fragile X Syndrome.

Authors:  Carly Moser; Laura Mattie; Leonard Abbeduto; Jessica Klusek
Journal:  Am J Intellect Dev Disabil       Date:  2021-11-01

7.  Rates and Predictors of Co-occurring Autism Spectrum Disorder in Boys with Fragile X Syndrome.

Authors:  Eileen Haebig; Audra Sterling; Andrea Barton-Hulsey; Laura Friedman
Journal:  Autism Dev Lang Impair       Date:  2020-02-12

8.  Brief Report: Linguistic Mazes and Perseverations in School-Age Boys with Fragile X Syndrome and Autism Spectrum Disorder and Relationships with Maternal Maze Use.

Authors:  Nell Maltman; Laura Friedman; Emily Lorang; Audra Sterling
Journal:  J Autism Dev Disord       Date:  2021-03-25

9.  Attention Bias and Prodromal Anxiety Symptoms in Toddlers With Fragile X Syndrome and Down Syndrome.

Authors:  Kayla Smith; Abigail L Hogan; Elizabeth Will; Jane E Roberts
Journal:  Am J Intellect Dev Disabil       Date:  2021-03-01

10.  Maternal Pragmatic Language Difficulties in the FMR1 Premutation and the Broad Autism Phenotype: Associations with Individual and Family Outcomes.

Authors:  Jessica Klusek; Angela John Thurman; Leonard Abbeduto
Journal:  J Autism Dev Disord       Date:  2021-04-04
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