| Literature DB >> 30382197 |
Fabien B Wagner1,2, Jean-Baptiste Mignardot1,2, Camille G Le Goff-Mignardot1,2, Karen Minassian1,2, Jocelyne Bloch2,3,4, Grégoire Courtine5,6,7,8, Robin Demesmaeker1,2, Salif Komi1,2, Marco Capogrosso9, Andreas Rowald1,2, Ismael Seáñez1,2, Miroslav Caban10,11, Elvira Pirondini1,2,12, Molywan Vat3, Laura A McCracken1,2, Roman Heimgartner1,2, Isabelle Fodor2, Anne Watrin10, Perrine Seguin1,2, Edoardo Paoles10, Katrien Van Den Keybus2, Grégoire Eberle2, Brigitte Schurch2, Etienne Pralong3, Fabio Becce13, John Prior14, Nicholas Buse15, Rik Buschman15, Esra Neufeld16, Niels Kuster16,17, Stefano Carda2, Joachim von Zitzewitz10, Vincent Delattre10, Tim Denison15,18, Hendrik Lambert10.
Abstract
Spinal cord injury leads to severe locomotor deficits or even complete leg paralysis. Here we introduce targeted spinal cord stimulation neurotechnologies that enabled voluntary control of walking in individuals who had sustained a spinal cord injury more than four years ago and presented with permanent motor deficits or complete paralysis despite extensive rehabilitation. Using an implanted pulse generator with real-time triggering capabilities, we delivered trains of spatially selective stimulation to the lumbosacral spinal cord with timing that coincided with the intended movement. Within one week, this spatiotemporal stimulation had re-established adaptive control of paralysed muscles during overground walking. Locomotor performance improved during rehabilitation. After a few months, participants regained voluntary control over previously paralysed muscles without stimulation and could walk or cycle in ecological settings during spatiotemporal stimulation. These results establish a technological framework for improving neurological recovery and supporting the activities of daily living after spinal cord injury.Entities:
Mesh：
Year: 2018 PMID： 30382197 DOI： 10.1038/s41586-018-0649-2
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962