Literature DB >> 3037865

Inhibition of sound-induced convulsions by metoprine in the audiogenic seizure susceptible rat.

L Tuomisto, U Tacke, A Willman.   

Abstract

Metoprine which increases brain histamine by blocking its methylation, was recently demonstrated to inhibit electrically induced tonic convulsions in rats. Its effect was now tested on audiogenic convulsions in genetically audiogenic seizure sensitive rats. Metoprine (20 mg/kg, i.p.) reduced the severity of seizures significantly 4 and 28 h after drug administration. Also the duration of convulsions was significantly decreased. These results agree with an involvement of histaminergic neurons in convulsive phenomena perhaps as a part of an anticonvulsive inhibitory transmitter system.

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Year:  1987        PMID： 3037865     DOI： 10.1007/BF02074683

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  7 in total

1.  Relationship between seizures and cyclic nucleotides in the central nervous system.

Authors:  J A Ferrendelli
Journal:  Adv Neurol       Date:  1983

2.  Is histamine an anticonvulsive inhibitory transmitter?

Authors:  L Tuomisto; U Tacke
Journal:  Neuropharmacology       Date:  1986-08       Impact factor: 5.250

3.  Histaminergic axons in the neostriatum and cerebral cortex of the rat: a correlated light and electron microscopic immunocytochemical study using histidine decarboxylase as a marker.

Authors:  H Takagi; Y Morishima; T Matsuyama; H Hayashi; T Watanabe; H Wada
Journal:  Brain Res       Date:  1986-01-29       Impact factor: 3.252

4.  Is adenosine an endogenous anticonvulsant?

Authors:  M Dragunow; G V Goddard; R Laverty
Journal:  Epilepsia       Date:  1985 Sep-Oct       Impact factor: 5.864

5.  Accumulations of cyclic AMP in adenine-labeled cell-free preparations from guinea pig cerebral cortex: role of alpha-adrenergic and H1-histaminergic receptors.

Authors:  J W Daly; E McNeal; C Partington; M Neuwirth; C R Creveling
Journal:  J Neurochem       Date:  1980-08       Impact factor: 5.372

6.  High-performance liquid chromatographic determination of plasma and brain histamine without previous purification of biological samples: cation-exchange chromatography coupled with post-column derivatization fluorometry.

Authors:  A Yamatodani; H Fukuda; H Wada; T Iwaeda; T Watanabe
Journal:  J Chromatogr       Date:  1985-11-08

7.  The effect of changes in sound pressure level and frequency on the seizure response of audiogenic seizure susceptible rats.

Authors:  U Tacke; E Björk; J Tuomisto
Journal:  J Pharmacol Methods       Date:  1984-07
  7 in total
  4 in total

1.  Magnesium deficiency-dependent audiogenic seizures (MDDASs) in adult mice: a nutritional model for discriminatory screening of anticonvulsant drugs and original assessment of neuroprotection properties.

Authors:  P Bac; P Maurois; C Dupont; N Pages; J P Stables; P Gressens; P Evrard; J Vamecq
Journal:  J Neurosci       Date:  1998-06-01       Impact factor: 6.167

Review 2.  Histamine H3 receptor antagonists in relation to epilepsy and neurodegeneration: a systemic consideration of recent progress and perspectives.

Authors:  M Bhowmik; R Khanam; D Vohora
Journal:  Br J Pharmacol       Date:  2012-12       Impact factor: 8.739

Review 3.  Brain Histamine N-Methyltransferase As a Possible Target of Treatment for Methamphetamine Overdose.

Authors:  Junichi Kitanaka; Nobue Kitanaka; F Scott Hall; George R Uhl; Motohiko Takemura
Journal:  Drug Target Insights       Date:  2016-03-02

Review 4.  Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs.

Authors:  Dubravka Svob Strac; Nela Pivac; Ilse J Smolders; Wieslawa A Fogel; Philippe De Deurwaerdere; Giuseppe Di Giovanni
Journal:  Front Neurosci       Date:  2016-11-10       Impact factor: 4.677
  4 in total

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