Literature DB >> 3022184

Is histamine an anticonvulsive inhibitory transmitter?

L Tuomisto, U Tacke.   

Abstract

This study was done to investigate the possible role of histaminergic systems in electroshock seizures. Brain histamine concentrations in rats were elevated by metoprine (i.p.), an inhibitor of histamine-N-methyltransferase. Animals were tested for their response to maximal electroshock (MES) at different times after the injection. Metoprine raised brain histamine concentrations and inhibited maximal hindleg extension after MES in a dose-dependent manner. Sensitivity to seizures correlated inversely with histamine concentrations. These results suggest that histaminergic neurones are involved in mechanisms which inhibit generalizations of epileptic discharges in the brain.

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Year:  1986        PMID： 3022184     DOI： 10.1016/0028-3908(86)90029-8

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  10 in total

1.  Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice.

Authors:  G Sturman; P Freeman; H M Meade; N A Seeley
Journal:  Agents Actions       Date:  1994-06

2.  Inhibition of sound-induced convulsions by metoprine in the audiogenic seizure susceptible rat.

Authors:  L Tuomisto; U Tacke; A Willman
Journal:  Agents Actions       Date:  1987-04

3.  Histamine and Seizures : Implications for the Treatment of Epilepsy.

Authors:  H Yokoyama; K Iinuma
Journal:  CNS Drugs       Date:  1996-05       Impact factor: 5.749

Review 4.  Histamine H3 receptor antagonists in relation to epilepsy and neurodegeneration: a systemic consideration of recent progress and perspectives.

Authors:  M Bhowmik; R Khanam; D Vohora
Journal:  Br J Pharmacol       Date:  2012-12       Impact factor: 8.739

5.  Proconvulsive effects of histamine H1-antagonists on electrically-induced seizure in developing mice.

Authors:  H Yokoyama; K Onodera; K Iinuma; T Watanabe
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

6.  Histamine levels and clonic convulsions of electrically-induced seizure in mice: the effects of alpha-fluoromethylhistidine and metoprine.

Authors:  H Yokoyama; K Onodera; K Maeyama; K Yanai; K Iinuma; L Tuomisto; T Watanabe
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-07       Impact factor: 3.000

Review 7.  Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs.

Authors:  Dubravka Svob Strac; Nela Pivac; Ilse J Smolders; Wieslawa A Fogel; Philippe De Deurwaerdere; Giuseppe Di Giovanni
Journal:  Front Neurosci       Date:  2016-11-10       Impact factor: 4.677

8.  Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats.

Authors:  Bassem Sadek; Ali Saad; Gniewomir Latacz; Kamil Kuder; Agnieszka Olejarz; Tadeusz Karcz; Holger Stark; Katarzyna Kieć-Kononowicz
Journal:  Drug Des Devel Ther       Date:  2016-11-25       Impact factor: 4.162

9.  Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats.

Authors:  Alaa Alachkar; Dorota Łażewska; Gniewomir Latacz; Annika Frank; Agata Siwek; Annamaria Lubelska; Ewelina Honkisz-Orzechowska; Jadwiga Handzlik; Holger Stark; Katarzyna Kieć-Kononowicz; Bassem Sadek
Journal:  Int J Mol Sci       Date:  2018-10-29       Impact factor: 5.923

10.  Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats.

Authors:  Alaa Alachkar; Sheikh Azimullah; Mohamed Lotfy; Ernest Adeghate; Shreesh K Ojha; Rami Beiram; Dorota Łażewska; Katarzyna Kieć-Kononowicz; Bassem Sadek
Journal:  Molecules       Date:  2020-03-30       Impact factor: 4.411
  10 in total

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