Literature DB >> 3037392

Evidence against a role of a pertussis toxin-sensitive guanine nucleotide-binding protein in the alpha 1-adrenoceptor-mediated positive inotropic effect in the heart.

M Böhm, W Schmitz, H Scholz.   

Abstract

Pertussis toxin, which specifically inactivates guanine nucleotide-binding proteins (N-proteins) involved in the signal transduction in various receptor systems, did not influence the positive inotropic effect of the alpha 1-adrenoceptor agonist phenylephrine in rat isolated left auricles. This indicates that the alpha 1-adrenoceptor-mediated positive inotropic effect does not involve a pertussis toxin-sensitive N-protein.

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Year:  1987        PMID： 3037392     DOI： 10.1007/BF00165566

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  8 in total

1.  Alpha 1-adrenoceptors reduce background K+ current in rabbit ventricular myocytes.

Authors:  D Fedida; A P Braun; W R Giles
Journal:  J Physiol       Date:  1991-09       Impact factor: 5.182

2.  Effects of pertussis toxin on alpha 1-agonist-mediated phosphatidylinositide turnover and myocardial cell hypertrophy in neonatal rat ventricular myocytes.

Authors:  J S Karliner; T Kagiya; P C Simpson
Journal:  Experientia       Date:  1990-01-15

Review 3.  On the mechanism of positive inotropic effects of alpha-adrenoceptor agonists.

Authors:  W Schmitz; C Kohl; J Neumann; H Scholz; J Scholz
Journal:  Basic Res Cardiol       Date:  1989       Impact factor: 17.165

Review 4.  [Inositol trisphosphate, a new "second messenger" for positive inotropic effects on the heart?].

Authors:  J Scholz
Journal:  Klin Wochenschr       Date:  1989-03-01

5.  Depolarization-induced influx of sodium in response to phenylephrine in rat atrial heart muscle.

Authors:  U Jahnel; H Nawrath; E Carmeliet; J Vereecke
Journal:  J Physiol       Date:  1991-01       Impact factor: 5.182

6.  Phorbol ester and the actions of phosphatidylinositol 4,5-bisphosphate specific phospholipase C and protein kinase C in microsomes prepared from cultured cardiomyocytes.

Authors:  J T Meij; K Bezstarosti; V Panagia; J M Lamers
Journal:  Mol Cell Biochem       Date:  1991-06-26       Impact factor: 3.396

7.  Properties of cardiac alpha- and beta-adrenoceptors in spontaneously hypertensive rats.

Authors:  M Böhm; D Beuckelmann; F Diet; G Feiler; M J Lohse; E Erdmann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-10       Impact factor: 3.000

8.  Activation of alpha 1-adrenoceptors modulates the inwardly rectifying potassium currents of mammalian atrial myocytes.

Authors:  A P Braun; D Fedida; W R Giles
Journal:  Pflugers Arch       Date:  1992-08       Impact factor: 3.657
  8 in total

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